Omega-3 fatty acids modulate ATPases involved in duodenal Ca absorption

Haag, M.; Magada, Olga N; Claassen, Nico; Böhmer, Linde H; Kruger, Marlena C.

doi:10.1016/s0952-3278(03)00067-x

Cited by 71 publications

(44 citation statements)

References 35 publications

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“…Other studies report that rats fed FO at a level similar to the present study, have lower prostaglandin E 2 [14]. FO may also favorably modulate bone metabolism by enhancing intestinal Ca absorption and reducing urinary Ca excretion [16].…”

Section: Discussionsupporting

confidence: 78%

“…Consumption of fish oil (FO), rich in omega-3 long chain PUFAs such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), has also been shown to favorably modulate bone metabolism, possibly via modulating inflammatory mediators including prostaglandin E 2 , IL-1b, IL-6, and TNF-a [13 -15] and/or directly affect intestinal calcium absorption [16]. One study has reported that feeding a diet containing soy ISO and FO to young (2 months old) ovariectomized rats protected against loss of tibia bone mineral content (BMC) but not bone mineral density (BMD), and reduced serum pyridinoline crosslinks, a biochemical marker of osteoclastic acitivity [17].…”

Section: Introductionmentioning

confidence: 99%

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Soy isoflavones and fatty acids: Effects on bone tissue postovariectomy in mice

Ward¹,

Fonseca

2007

Molecular Nutrition Food Res

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Osteoporosis is a silent disease that leads to fragility fractures that can diminish quality of life and contribute to death. With no ideal drug treatment available to manage osteoporosis, soy isoflavones (ISO), and omega-3 long chain PUFAs in fish oil (FO) may be integral in a dietary strategy that prevents bone loss. The overall objective of this study was to determine if combining ISO with omega-3 long chain PUFAs resulted in greater protection against the loss of bone mineral and skeletal weakening in ovariectomized mice. Ovariectomized CD-1 mice were randomized to control diet or a diet containing ISO alone (250 mg of genistein + 250 mg of daidzein/kg diet), FO alone (7% menhaden oil), or ISO + FO. Each dietary intervention prevented the loss of bone mineral density (BMD) in the femur and preserved femur strength, but only FO, either alone or combined with ISO, resulted in a higher BMD of lumbar vertebra (LV). Most notably, FO + ISO resulted in a higher peak load of LV4, indicating that vertebra were more resistant to fracture. Whether a dietary strategy providing FO in combination with ISO attenuates bone loss in postmenopausal women awaits investigation.

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Section: Discussionsupporting

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Soy isoflavones and fatty acids: Effects on bone tissue postovariectomy in mice

Ward¹,

Fonseca

2007

Molecular Nutrition Food Res

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“…In growing rats fed either sunflower oil or fish oil for 12 weeks, fish oil fed rats displayed increased calcium balance and increased absorption by the small intestine [44]. Enterocytes isolated from rat small intestine were exposed to EPA, DHA or AA, and it was demonstrated that only DHA was able to increase basal calcium absorption by increasing the activity of Ca-ATPase, which represents the rate limiting enzyme in calcium uptake [45]. By increasing calcium absorption, more calcium is available to be incorporated into the bone mineral matrix.…”

Section: Mechanisms Of Pufa In Bone Metabolismmentioning

confidence: 99%

Investigating the Role of Polyunsaturated Fatty Acids in Bone Development Using Animal Models

et al. 2013

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Incorporating n-3 polyunsaturated fatty acids (PUFA) in the diet may promote the development of a healthy skeleton and thereby reduce the risk of developing osteoporosis in later life. Studies using developing animal models suggest lowering dietary n-6 PUFA and increasing n-3 PUFA intakes, especially long chain n-3 PUFA, may be beneficial for achieving higher bone mineral content, density and stronger bones. To date, the evidence regarding the effects of α-linolenic acid (ALA) remain equivocal, in contrast to evidence from the longer chain products, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). This review reports the results of investigations into n-3 PUFA supplementation on bone fatty acid composition, strength and mineral content in developing animal models as well as the mechanistic relationships of PUFA and bone, and identifies critical areas for future research. Overall, this review supports a probable role for essential (ALA) and long chain (EPA and DHA) n-3 PUFA for bone health. Understanding the role of PUFA in optimizing bone health may lead to dietary strategies that promote bone development and maintenance of a healthy skeleton.

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“…Adequate levels of this vitamin are obtained by suitable intake and sufficient exposure to sunlight, which is the major source of vitamin D in the organism (Bener et al, 2008). On the other hand, certain lipids may favor calcium bioavailability; it has been shown that a high ratio of unsaturated to saturated fatty acids has beneficial effects on calcium absorption (Haag et al, 2003). Fish may be a good source of calcium because on the one hand its protein is as positive as casein in promoting calcium absorption (García-Arias et al, 1994), and on the other hand because omega-3 fatty acid might promote calcium transport (Haag et al, 2003).…”

Section: Calciummentioning

confidence: 99%

“…On the other hand, certain lipids may favor calcium bioavailability; it has been shown that a high ratio of unsaturated to saturated fatty acids has beneficial effects on calcium absorption (Haag et al, 2003). Fish may be a good source of calcium because on the one hand its protein is as positive as casein in promoting calcium absorption (García-Arias et al, 1994), and on the other hand because omega-3 fatty acid might promote calcium transport (Haag et al, 2003). It should be noted that the positive effect of fish fat in calcium utilization is promoted when it is consumed together with olive oil (Pérez-Granados et al, 2000), as it occurs when fried fish are consumed.…”

Section: Calciummentioning

confidence: 99%