Omentin as an Independent Predictor of Metabolic Syndrome and Obesity Among Adolescents in Northeast China

Sun, Xiaoshi; Li, Tianlian; Tian, Ye; Ren, Shuying; Li, Ling; Li, Ping

doi:10.2147/dmso.s388620

Cited by 4 publications

(3 citation statements)

References 52 publications

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“…The healthy subjects in the study by Luedde et al were younger than patients and their BMI was not reported, while in our study the cases and controls were age- and gender-matched and the BMI was not significantly different [ 42 ]. Since serum omentin-1 has been shown to be inversely related to BMI, this may have been a confounding factor in the study by Luedde et al [ 5 , 42 , 66 , 67 ]. Moreover, our patients had more severe diseases, as reflected by the higher APACHE II scores.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic and Prognostic Value of Serum Omentin-1 in Sepsis: A Prospective Study in Critically Ill Patients

et al. 2023

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Background and Objectives: Omentin-1, also known as intelectin-1, is a novel adipokine with anti-inflammatory activities implicated in inflammatory diseases and sepsis. We aimed to explore serum omentin-1 and its kinetics in critically ill patients early in sepsis and its association with severity and prognosis. Materials and Methods: Serum omentin-1 was determined in 102 critically ill patients with sepsis during the first 48 h from sepsis onset and 1 week later, and in 102 age- and gender-matched healthy controls. The outcome of sepsis at 28 days after enrollment was recorded. Results: Serum omentin-1 at enrollment was significantly higher in patients compared to controls (763.3 ± 249.3 vs. 451.7 ± 122.3 μg/L, p < 0.001) and it further increased 1 week after (950.6 ± 215.5 vs. 763.3 ± 249.3 μg/L, p < 0.001). Patients with septic shock (n = 42) had higher omentin-1 compared to those with sepsis (n = 60) at enrollment (877.9 ± 241.2 vs. 683.1 ± 223.7 μg/L, p < 0.001) and 1 week after (1020.4 ± 224.7 vs. 901.7 ± 196.3 μg/L, p = 0.007). Furthermore, nonsurvivors (n = 30) had higher omentin-1 at sepsis onset (952.1 ± 248.2 vs. 684.6 ± 204.7 μg/L, p < 0.001) and 1 week after (1051.8 ± 242 vs. 908.4 ± 189.8 μg/L, p < 0.01). Patients with sepsis and survivors presented higher kinetics than those with septic shock and nonsurvivors (Δ(omentin-1)% 39.8 ± 35.9% vs. 20.2 ± 23.3%, p = 0.01, and 39.4 ± 34.3% vs. 13.3 ± 18.1%, p < 0.001, respectively). Higher omentin-1 at sepsis onset and 1 week after was an independent predictor of 28-day mortality (HR 2.26, 95% C.I. 1.21–4.19, p = 0.01 and HR: 2.15, 95% C.I. 1.43–3.22, p < 0.001, respectively). Finally, omentin-1 was significantly correlated with the severity scores, the white blood cells, coagulation biomarkers, and CRP, but not procalcitonin and other inflammatory biomarkers. Conclusions: Serum omentin-1 is increased in sepsis, while higher levels and lower kinetics during the first week of sepsis are associated with the severity and 28-day mortality of sepsis. Omentin-1 may be a promising biomarker of sepsis. However, more studies are needed to explore its role in sepsis.

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Section: Discussionmentioning

confidence: 99%

Diagnostic and Prognostic Value of Serum Omentin-1 in Sepsis: A Prospective Study in Critically Ill Patients

et al. 2023

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“…Omentin is a newly identified adipokine; it is a protein with a body weight of 38 kDa. Omentin is predominantly expressed in visceral adipose tissue and is secreted mainly from stromal vascular cells rather than adipocytes [93]. The expression of omentin decreases in patients with obesity, insulin resistance, and diabetes mellitus.…”

Section: Omentinmentioning

confidence: 99%

“…So, omentin has been proposed as a MetS biomarker and a biomarker of endothelial dysfunction in patients with MetS [93]. It has been shown that the level of omentin does not change during treatment with valproate [94], but studies on this topic are also singular, requiring the further study of omentin as a potential metabolic biomarker of VPA-MetS.…”

Section: Omentinmentioning

confidence: 99%

Valproate-Induced Metabolic Syndrome

Shnayder,

Grechkina,

Trefilova

et al. 2023

Biomedicines

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Valproic acid (VPA) and its salts (sodium calcium magnesium and orotic) are psychotropic drugs that are widely used in neurology and psychiatry. The long-term use of VPA increases the risk of developing adverse drug reactions (ADRs), among which metabolic syndrome (MetS) plays a special role. MetS belongs to a cluster of metabolic conditions such as abdominal obesity, high blood pressure, high blood glucose, high serum triglycerides, and low serum high-density lipoprotein. Valproate-induced MetS (VPA-MetS) is a common ADR that needs an updated multidisciplinary approach to its prevention and diagnosis. In this review, we consider the results of studies of blood (serum and plasma) and the urinary biomarkers of VPA-MetS. These metabolic biomarkers may provide the key to the development of a new multidisciplinary personalized strategy for the prevention and diagnosis of VPA-MetS in patients with neurological diseases, psychiatric disorders, and addiction diseases.

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Diverse Cytokines Secreted by Adipocyte in Linking Cardio-Metabolic Disorder and SLE

Lai,

Lin,

Chen

et al. 2024

Front. Biosci. (Landmark Ed)

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Systemic lupus erythematosus (SLE) is a multi-factorial autoimmune-mediated disease with hyper-stimulation of immune cells especially the T lymphocytes. By this method, it might facilitate the systematic damages in multiple tissues and organs. Otherwise, SLE is also correlated with diverse cardio-metabolic comorbidities, including dyslipidemia, insulin resistance, and hypertension. It is worth-noting that the risk of cardio-metabolic disorders is significantly higher compared with the healthy patients which was reported as approximately one-third of SLE patients were proved as obesity. Notably, current focus is shifting to implementing cardio-metabolic protective strategies as well as elucidating underlying mechanisms of lupus-mediated obese status. On the other hand, adipocyte, as the most abundant endocrine cell in fat tissue, are dysfunctional in obese individuals with aberrant secretion of adipokines. It is proposing that the adipokine might link the pathology of cardio-metabolic disorders and SLE, whereas the related mechanism is complicated. In the current review, the functions of adipokine and the potential mechanisms by which the adipokine link cardio-metabolic disorders and SLE was well listed. Furthermore, the recommendations, which identify the adipokine as the potential therapeutic targets for the treatment of cardio-metabolic disorders and SLE, were also summarized.

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Omentin as an Independent Predictor of Metabolic Syndrome and Obesity Among Adolescents in Northeast China

Cited by 4 publications

References 52 publications

Diagnostic and Prognostic Value of Serum Omentin-1 in Sepsis: A Prospective Study in Critically Ill Patients

Diagnostic and Prognostic Value of Serum Omentin-1 in Sepsis: A Prospective Study in Critically Ill Patients

Valproate-Induced Metabolic Syndrome

Diverse Cytokines Secreted by Adipocyte in Linking Cardio-Metabolic Disorder and SLE

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