Omics approaches to study juvenile hormone synthesis

Nouzová, Marcela; Rivera-Pérez, Crisalejandra; Noriega, Fernando G.

doi:10.1016/j.cois.2018.05.013

Cited by 12 publications

(9 citation statements)

References 85 publications

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“…For this we treated 4 th instar nymphs of BPH with the LC 50 concentration of EB using systemic bioassays, and then collected early (5E), middle (5M) and late (5L) stage of 5 th instar nymph and 1-7 DAE female adults (DAE) for analysis. Quantitative PCR was then used to examine the expression of key genes previously implicated in the regulation of JH (35, 36).…”

Section: Resultsmentioning

confidence: 99%

Pesticide-induced resurgence in brown planthopper is mediated by action on a suite of genes that promote juvenile hormone biosynthesis and female fecundity

Gao,

Su,

Xing

et al. 2023

Preprint

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Pesticide-induced resurgence, increases in pest insect populations following pesticide application, is a serious threat to the sustainable control of many highly damaging crop pests. Resurgence can result from pesticide-enhanced pest reproduction, however, the molecular mechanisms mediating this process remain unresolved. Here we show that brown planthopper (BPH) resurgence following emamectin benzoate (EB) exposure results from the coordinated action of a diverse suite of actors that regulate juvenile hormone (JH) levels, resulting in increased JH titer in adult females and enhanced fecundity. Following reports of BPH resurgence in rice crops when this species is exposed to EB, we demonstrate that EB treatment results in profound changes in female BPH fitness including enhanced ovary development and elevated egg production. This enhanced reproductive fitness results from the EB-mediated upregulation of key genes involved in the regulation of JH, including JHAMT, Met and Kr-h1 and the downregulation of allatostatin (AstA) and allatostatin receptor (AstAR) expression. The remodulation of gene expression following EB exposure is dependent on the action of this insecticide on its molecular target the glutamate-gated chloride channel (GluCl) receptor. Collectively, these results provide mechanistic insights into the regulation of negative pesticide-induced responses in insects and reveal the key actors involved in the JH-signaling pathway that underpin pesticide resurgence.

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Section: Resultsmentioning

confidence: 99%

Pesticide-induced resurgence in brown planthopper is mediated by action on a suite of genes that promote juvenile hormone biosynthesis and female fecundity

Gao,

Su,

Xing

et al. 2023

Preprint

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“…A possible explanation is that signaling factors responsible for JH synthesis might be turned on specifically at Mid-PAE of female locusts upon 4-VA stimuli, such as GPCRs and transcription factors ( Bendena et al, 2020 ). Although there are only a few DEGs in the brain of females exposed to 4-VA, we cannot exclude the involvement of the central nerve system pathway by other regulatory mechanisms, for example, neurotransmitter release, or post-transcription regulation ( Nouzova et al, 2018 ). Further studies should elucidate detailed mechanisms of the linking between 4-VA and JH biosynthesis in female locusts.…”

Section: Discussionmentioning

confidence: 97%

Aggregation pheromone 4-vinylanisole promotes the synchrony of sexual maturation in female locusts

Chen

Wei

et al. 2022

eLife

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Reproductive synchrony generally occurs in various group-living animals. However, the underlying mechanisms remain largely unexplored. The migratory locust, Locusta migratoria, a worldwide agricultural pest species, displays synchronous maturation and oviposition when forms huge swarm. The reproductive synchrony among group members is critical for the maintenance of locust swarms and population density of next generation. Here, we showed that gregarious female locusts displayed more synchronous sexual maturation and oviposition than solitarious females and olfactory deficiency mutants. Only the presence of gregarious male adults can stimulate sexual maturation synchrony of female adults. Of the volatiles emitted abundantly by gregarious male adults, the aggregation pheromone, 4-vinylanisole, was identified to play key role in inducing female sexual maturation synchrony. This maturation-accelerating effect of 4-vinylanisole disappeared in the females of Or35-/- lines, the mutants of 4-vinylanisole receptor. Interestingly, 4-vinylanisole displayed a time window action by which mainly accelerates oocyte maturation of young females aged at middle developmental stages (3–4 days post adult eclosion). We further revealed that juvenile hormone/vitellogenin pathway mediated female sexual maturation triggered by 4-vinylanisole. Our results highlight a ‘catch-up’ strategy by which gregarious females synchronize their oocyte maturation and oviposition by time-dependent endocrinal response to 4-vinylanisole, and provide insight into reproductive synchrony induced by olfactory signal released by heterosexual conspecifics in a given group.

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“…In particular, in the recent decade, several analyses of the peptidome of the CA have been undertaken. Liu et al (2012) could assign a total of 41 ion masses present in the CC-CA complex of fifth instar Bombyx mori but no clear-cut candidate for a peptide that is only secreted by the Golgi of the CA was found in this or other (e.g., Nouzova et al, 2018b) mass spectrometric studies.…”

Section: Gland Cells Of the Corpora Allata Have Golgi Systems: A Probmentioning

confidence: 96%

Two Undervalued Functions of the Golgi Apparatus: Removal of Excess Ca2+ and Biosynthesis of Farnesol-Like Sesquiterpenoids, Possibly as Ca2+-Pump Agonists and Membrane “Fluidizers–Plasticizers”

Loof

Schoofs

2020

Front. Physiol.

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The extensive literature dealing with the Golgi system emphasizes its role in protein secretion and modification, usually without specifying from which evolutionary ancient cell physiological necessity such secretion originated. Neither does it specify which functional requirements the secreted proteins must meet. From a reinterpretation of some classical and recent data gained mainly, but not exclusively, from (insect) endocrinology, the view emerged that the likely primordial function of the rough endoplasmic reticulum (RER)-Golgi complex in all eukaryotes was not the secretion of any type of protein but the removal of toxic excess Ca 2+ from the cytoplasm. Such activity requires the concurrent secretion of large amounts of Ca 2+-carrying/transporting proteins acting as a micro-conveyor belt system inside the RER-Golgi. Thus, (fitness increasing) protein secretion is subordinate to Ca 2+ removal. Milk with its high content of protein and Ca 2+ (60-90 mM vs. 100 nM in unstimulated mammary gland cells) is an extreme example. The sarco(endo)plasmatic reticulum Ca 2+-ATPases (SERCAs) and SPCA1a Ca 2+ /Mn 2+ transport ATPases are major players in Ca 2+ removal through the Golgi. Both are blocked by the sesquiterpenoid thapsigargin. This strengthens the hypothesis (2014) that endogenous farnesol-like sesquiterpenoids (FLSs) may act as the long sought for but still unidentified agonist(s) for Ca 2+-pumps in both the ER and Golgi. A second putative function also emerges. The fusion of both the incoming and outgoing transport vesicles, respectively, at the cis-and trans-side of Golgi stacks, with the membrane system requiring high flexibility and fast self-closing of the involved membranes. These properties may-possibly partially-be controlled by endogenous hydrophobic membrane "fluidizers" for which FLSs are prime candidates. A recent reexamination of unexplained classical data suggests that they are likely synthesized by the Golgi itself. This game-changing hypothesis is endorsed by several arguments and data, some of which date from 1964, that the insect corpus allatum (CA), which is the major production site of farnesol-esters, has active Golgi systems. Thus, in addition to

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Omics approaches to study juvenile hormone synthesis

Cited by 12 publications

References 85 publications

Pesticide-induced resurgence in brown planthopper is mediated by action on a suite of genes that promote juvenile hormone biosynthesis and female fecundity

Pesticide-induced resurgence in brown planthopper is mediated by action on a suite of genes that promote juvenile hormone biosynthesis and female fecundity

Aggregation pheromone 4-vinylanisole promotes the synchrony of sexual maturation in female locusts

Two Undervalued Functions of the Golgi Apparatus: Removal of Excess Ca2+ and Biosynthesis of Farnesol-Like Sesquiterpenoids, Possibly as Ca2+-Pump Agonists and Membrane “Fluidizers–Plasticizers”

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