omparative analysis between tuberculous meningitis and other forms of extrapulmonary tuberculosis

Hammami, Fatma; Chakroun, Amal; Rekik, Khaoula; Feki, W.; Marrakchi, Chakib; Smaoui, Fatma; Jemâa, Mounir Ben

doi:10.18683/germs.2021.1237

Cited by 5 publications

(2 citation statements)

References 26 publications

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“…Tuberculosis and brucellosis both classified as Class B infectious diseases. Both are great mimickers with multisystemic involvement [ 9 – 11 ], when these infections involve the central nervous system, they can lead to neurobrucellosis and tuberculous meningitis respectively. The most fatal form of tuberculosis, tuberculous meningitis.…”

Section: Discussionmentioning

confidence: 99%

A comparison of clinical features between neurobrucellosis and tuberculous meningitis

Zou,

Wang,

et al. 2024

BMC Neurol

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Backgroud This study aims to compare the clinical manifestations, imaging findings, routine tests, biochemistry indicators and cerebrospinal fluid cytology between neurobrucellosis and tuberculous meningitis. The objective is to evaluate the similarities and differences of these two diseases and improve early diagnosis. Methods A comprehensive evaluation was conducted by comparing clinical data, imaging results, routine tests findings, biochemistry indicators and cerebrospinal fluid cytology of patients admitted to the Department of Neurology, the Second Hospital of Hebei Medical University from 2019 to 2021. Statistical analysis was applied to identify significant differences and similarities between the two diseases. Results Preliminary analysis demonstrated both diseases commonly present with symptoms such as fever, headache. However, there were no statistical differences between neurobrucellosis and tuberculous meningitis in early clinical data, imaging results, routine tests findings, biochemistry indicators. Further analysis indicates there is a statistically significantly difference in the lymphocyte ratio and neutrophil ratio in the cerebrospinal fluid between the two groups. Conclusions Neurobrucellosis and tuberculous meningitis share similarities in early clinical manifestations, imaging findings and initial cerebrospinal fluid parametes, making early-stage differentiation challenging. The ratio of lymphocytes and neutrophil in the cerebrospinal fluid and a detailed medical history investigation can provide clues for early clinical diagnosis. So the examination of CSF cytology might be a potential to distinguish these two diseases and become a powerful tool in the future.

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Section: Discussionmentioning

confidence: 99%

A comparison of clinical features between neurobrucellosis and tuberculous meningitis

Zou,

Wang,

et al. 2024

BMC Neurol

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“…Medical image storage and transmission data refers to images generated by daily ultrasound, various X-ray machines, nuclear magnetic resonance, electronic computed tomography, various infrared instruments, microscopes and other equipment that are stored in digital technology [10][11]. The maximum convenience of personnel allows them to see the results of the patient's inspection and analysis in the shortest time, thereby providing laboratory evidence for diagnosis and treatment activities [12].…”

Section: 1smart Big Datamentioning

confidence: 99%

Clinical Medical Equipment Disinfection in Children with Mycoplasma Pneumoniae Pneumonia and Extrapulmonary Complications Based on Smart Big Data

2022

IJHPM

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Mycoplasma pneumoniae pneumonia (MPP) is mostly benign and self-limiting. After regular treatment with macrolide antibacterial drugs, most of them can heal themselves, but severe MPP will have serious complications, such as hypoxia and respiratory failure. Therefore, this article conducts clinical research on children's MPP and extrapulmonary complications based on the disinfection of smart big data(BD) medical equipment, discusses the clinical characteristics and changes of lung function in children with MPP in different degrees of illness, and provides a certain theoretical basis for the timely diagnosis and treatment of children with MPP. This article adopts a retrospective analysis method to select 88 MPP patients who were hospitalized in a pediatric department of a hospital from March 2019 to February 2020. According to the severity of the disease, they were divided into a severe MPP group and a mild MPP group. According to their clinical manifestations, they were divided into a severe MPP group and a mild MPP group. The wheezing group and the non-wheezing group are divided into the acute phase and the recovery phase according to the period of the disease. The clinical manifestations, laboratory indicators, chest imaging findings, and complications are compared and analyzed. The experiment proved that there were 33 cases in the severe MPP group, the average duration of fever was 11.09±4.72 days, the average duration of cough was 17.46±3.37 days, and the average hospital stay was 11.32±5.47 days; there were 55 cases in the mild MPP group, and the average fever the duration was 8.59±3.79 days, the average duration of cough was 13.89±3.97 days, and the average hospital stay was 6.97±2.29 days. This shows that the disinfection of medical equipment based on smart BD plays a role in the treatment of children's MPP and extrapulmonary complications, and provides a certain theoretical basis for the clinical treatment of children's MPP.

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Central Nervous System Tuberculosis: Risk Factors for Mortality in a Propensity Score–Matched Case-Control Study

Asare-Baah,

Johnston,

Ramirez-Hiller

et al. 2023

Open Forum Infectious Diseases

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Background Despite advancements in tuberculosis (TB) control and treatment in the United States (US), patients with central nervous system TB (CNS-TB) continue to experience significantly higher mortality rates than those without CNS-TB. This raises concerns regarding clinical management and the need for a deeper understanding of the risk factors contributing to these deaths. This study aimed to determine the predictors of mortality in patients with CNS-TB. Methods We conducted a retrospective 1:2 propensity-score-matched case-control study. Cases were TB patients diagnosed with TB of the meninges, brain, spinal cord, or peripheral nerves, as documented in the Florida Department of Health (FDOH) TB registry, between 2009 and 2021. Controls were TB patients without CNS-TB, also reported in the FDOH TB registry during the same timeframe. We employed conditional logistic regression models to investigate the factors contributing to mortality in cases compared with controls. Results We analyzed data from 116 cases and 232 matched controls. Patients with CNS-TB had a 5.69-fold higher risk of death than those without CNS-TB (aOR = 5.69, 95% CI: 2.91, 11.6). Increased risk of death was associated with HIV co-infection (aOR = 1.93, 95% CI: 0.82, 4.37) and diabetes (aOR = 3.13, 95% CI: 1.28, 7.47). Miliary TB and non-HIV immunosuppression were significantly associated with being a case, while cavitary TB was less likely to be associated with being a case. Conclusions Clinical management should prioritize screening and close monitoring of patients with HIV co-infection and diabetes to improve patient outcomes.

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omparative analysis between tuberculous meningitis and other forms of extrapulmonary tuberculosis

Cited by 5 publications

References 26 publications

A comparison of clinical features between neurobrucellosis and tuberculous meningitis

A comparison of clinical features between neurobrucellosis and tuberculous meningitis

Clinical Medical Equipment Disinfection in Children with Mycoplasma Pneumoniae Pneumonia and Extrapulmonary Complications Based on Smart Big Data

Central Nervous System Tuberculosis: Risk Factors for Mortality in a Propensity Score–Matched Case-Control Study

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