On a p ( x ) $p(x)$ -biharmonic problem with Navier boundary condition

Zhou, Zheng

doi:10.1186/s13661-018-1071-2

Cited by 21 publications

(31 citation statements)

References 29 publications

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“…In 2014, the Liang group reported the ipso vinylation/ortho alkylation using N-tosylhydrazones as the nucleophile (Scheme 38). 86 The base employed was important, as it was needed for both the C-H metalation and diazo species generation steps. During Liang's study, Cs 2 CO 3 was found to be more effective than LiO t Bu.…”

Section: Ortho Alkylation Of Aryl Iodidesmentioning

confidence: 99%

“…Interestingly, if the termination nucleophile is attached to the aryl halide, fused tricyclic structures could be formed (84b). 123 Besides ipso Heck coupling, ipso cyanation 83 and vinylation via carbene insertion 86,124 have been established with aryl iodides and bromides under the intramolecular type-C reaction mode. Recently, the Liang group utilized a Pd/Cu cocatalyst system to synthesize polyfluoroarene-substituted benzofuran and benzopyran derivatives, 125 where a polyflouoroaryl copper species was believed to be the key intermediate.…”

Section: Intramolecular Couplingsmentioning

confidence: 99%

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Palladium/Norbornene Cooperative Catalysis

2019

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Palladium/norbornene cooperative catalysis has emerged as a distinct approach to construct polyfunctionalized arenes from readily available starting materials. This Review provides a comprehensive overview of this field, including the early stoichiometric investigations, catalytic reaction developments, as well as the applications in the syntheses of bioactive compounds and polymers. The section of catalytic reactions is divided into two parts according to the reaction initiation mode: Pd(0)-initiated reactions and Pd(II)-initiated reactions.

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Section: Ortho Alkylation Of Aryl Iodidesmentioning

confidence: 99%

Section: Intramolecular Couplingsmentioning

confidence: 99%

Palladium/Norbornene Cooperative Catalysis

2019

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“…As of April 21 st , 2020, a total of 2,395,822 confirmed cases have been reported in 200 countries/territories/areas around the world. reading frame (ORF) proteins [1,2]. In this study, we developed a magnetic chemiluminescence enzyme immunoassay (MCLIA), which showed high specificity and sensitivity in detecting serum immunoglobulin G (IgG) and IgM against SARS-CoV-2.…”

Section: Introductionmentioning

confidence: 99%

A Peptide-Based Magnetic Chemiluminescence Enzyme Immunoassay for Serological Diagnosis of Coronavirus Disease 2019

Cai

Chen

et al. 2020

The Journal of Infectious Diseases

152

132

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SARS-CoV-2, a novel ß-coronavirus, cause severe pneumonia and has spread throughout the globe rapidly. The disease associated with SARS-CoV-2 infection is named COVID-19. To date, real-time RT-PCR is the only test able to confirm this infection. However, the accuracy of RT-PCR depends on several factors; variations in these factors might significantly lower the sensitivity of detection. Here, we developed a peptide-based luminescent immunoassay that detected immunoglobulin G (IgG) and IgM. The assay cut-off value was determined by evaluating the sera from healthy and infected patients for pathogens other than SARS-CoV-2. To evaluate assay performance, we detected IgG and IgM in the sera from confirmed patients. The positive rate of IgG and IgM was 71.4% and 57.2%, respectively. Therefore, combining our immunoassay with real-time RT-PCR might enhance the diagnostic accuracy of COVID-19.

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“…According to World Health Organization (WHO) as of June 27 th 2020, there has been about 10 million confirmed cases and approaching 500,000 deaths due to coronavirus in the world. [1][2] Much of the human population including the United States of America were under lockdown or official stay-at-home orders to minimize the continued spread of the virus.…”

Section: Introductionmentioning

confidence: 99%

Critical Sequence Hot-spots for Binding of nCOV-2019 to ACE2 as Evaluated by Molecular Simulations

Ghorbani

Brooks

Klauda

2020

Preprint

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The novel coronavirus (nCOV-2019) outbreak has put the world on edge, causing millions of cases and hundreds of thousands of deaths all around the world, as of June 2020, let alone the societal and economic impacts of the crisis. The spike protein of nCOV-2019 resides on the virion's surface mediating coronavirus entry into host cells by binding its receptor binding domain (RBD) to the host cell surface receptor protein, angiotensin converter enzyme (ACE2).Our goal is to provide a detailed structural mechanism of how nCOV-2019 recognizes and establishes contacts with ACE2 and its difference with an earlier coronavirus SARS-COV in 2002 via extensive molecular dynamics (MD) simulations. Numerous mutations have been identified in the RBD of nCOV-2019 strains isolated from humans in different parts of the world.In this study, we investigated the effect of these mutations as well as other Ala-scanning mutations on the stability of RBD/ACE2 complex. It is found that most of the naturallyoccurring mutations to the RBD either strengthen or have the same binding affinity to ACE2 as the wild-type nCOV-2019. This may have implications for high human-to-human transmission of coronavirus in regions where these mutations have been found as well as any vaccine design endeavors since these mutations could act as antibody escape mutants. Furthermore, in-silico Ala-scanning and long-timescale MD simulations, highlight the crucial role of the residues at the interface of RBD and ACE2 that may be used as potential pharmacophores for any drug development endeavors. From an evolutional perspective, this study also identifies how the virus has evolved from its predecessor SARS-COV and how it could further evolve to become more infectious.

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On a p ( x ) $p(x)$ -biharmonic problem with Navier boundary condition

Abstract: In this paper, we study a p(x)-biharmonic equation with Navier boundary condition 2inf x∈ a(x) = a -> 0. By variational methods, we establish the results of existence and non-existence of solutions.

Cited by 21 publications

References 29 publications

Palladium/Norbornene Cooperative Catalysis

Palladium/Norbornene Cooperative Catalysis

A Peptide-Based Magnetic Chemiluminescence Enzyme Immunoassay for Serological Diagnosis of Coronavirus Disease 2019

Critical Sequence Hot-spots for Binding of nCOV-2019 to ACE2 as Evaluated by Molecular Simulations

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