On and On the Temporal Way

Dixon, Clare; Fisher, Michael

doi:10.29007/sz8j

EPiC Series in Computing

DOI: 10.29007/sz8j

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On and On the Temporal Way

Clare Dixon

Michael Fisher

Abstract: Abstract"Up and Down the Temporal Way" was a paper published by Howard Barringer in the 1980s that used temporal logics to formally specify a lift system. Based on that temporal specification, we describe some advances and extensions to temporal specification and verification that the authors have been involved with since then.

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“…55]. During stress, /?-endorphin is released in increased quantities from the anterior pituitary [20.43] and enkephaiins from the adrenal medulla [16,29]. Since these substances have potent immunomodulatory actions, it has been suggested that endogenous opioids may be responsible for the immunosuppression associated with stress [45.…”

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Naloxone‐Reversible Monocyte Dysfunction in Patients with Chronic Fatigue Syndrome

et al. 1989

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We studied monocyte function in 35 consecutive patients with chronic fatigue syndrome (CFS) and 25 healthy controls. Eighty-five per cent of the patients showed monocyte dysfunction characterized by marked reduction in the number of monocytes displaying immunoreactive cytoskeletal vimentin filaments, a low phagocytosis index, and a reduced expression of HLA-DR antigens. These values increased dramatically after incubation of the patients' monocytes with the opioid antagonist naloxone. Other immunological abnormalities also noted in the patients were low lymphocyte blastogenesis and diminished numbers of monocytes displaying receptors for Fc of IgG (FcR) and C3b (CR1). These findings suggest that an increased opioid activity acting through a classical receptor mechanism is active on monocytes from a high proportion of patients with CFS and that this represents a novel example of immunomodulation by opioid peptides in human disease. We suggest that endogenous opioids are involved in the pathogenesis of the chronic fatigue syndrome.

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Naloxone‐Reversible Monocyte Dysfunction in Patients with Chronic Fatigue Syndrome

et al. 1989

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On and On the Temporal Way

Cited by 1 publication

References 37 publications

Naloxone‐Reversible Monocyte Dysfunction in Patients with Chronic Fatigue Syndrome

Naloxone‐Reversible Monocyte Dysfunction in Patients with Chronic Fatigue Syndrome

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