On-column internal standardisation as an alternative calibration strategy for speciation analysis: feasibility demonstration through analysis of inorganic As in rice

Abstract

Species-specific isotope dilution mass spectrometry (SS-IDMS) has been the calibration method of choice for high accuracy speciation analysis because it can correct for detector sensitivity drifts, matrix effects, analyte loss...

Atomic spectrometry update: review of advances in elemental speciation

“…On-column internal standardisation as an alternative calibration strategy for speciation analysis has been demonstrated using the analysis of iAs in rice. 54 The calibration method of choice for high accuracy speciation analysis is ssIDMS because it can correct for detector sensitivity dri, matrix effects, and analyte loss during sample preparation and analysis. However, in many cases, ssIDMS calibration is either not applicable (e.g.…”

Atomic spectrometry update – a review of advances in environmental analysis

“…The coupling of chromatographic separation with ICP-MS remained of interest. Of particular note was a HPLC-ICP-MS method 180 for determination of inorganic As species in rice. A novel on-column species-specific internal-calibration-strategy was proposed to overcome challenges associated with ID, such as cost and non-availability of suitable isotopically enriched standards.…”

Atomic spectrometry update: review of advances in the analysis of clinical and biological materials, foods and beverages

“…, cost or availability of isotopically enriched species or measuring monoisotopic elements. Petrov et al 82 employed a novel on-column IS strategy, which involved chromatographic injection of the analyte species as an IS following the sample injection. Analysis of a standard containing MMA and As V demonstrated that the approach may be used for multiple species as long as there is adequate resolution of the species.…”