This article deals, the pulsating flow of blood carrying Au/CuO Oldroyd-B nanofluid through a porous channel with the effects of viscous dissipation, thermal radiation, and Joule (Ohmic) heating, and applied magnetic field. The perturbation technique is employed to get analytic solutions for flow variables.A comparison between analytical and numerical results shows a good agreement. The effect of various parameters is addressed extensively aided by pictorial results. The obtained results present that the velocity is reduced with the higher values of Hartmann number and volume fraction of nanoparticles. The temperature of nanofluid is enhanced with an enhancement of Eckert number and radiation parameter while it reduces with a rise in Hartmann number. Furthermore, the rise of the volume fraction of nanoparticles boosts up the rate of heat transfer.