On Meningococcal Disease, Its Prognosis, and Undernotification of the Public Health Service

Nonell, Ferran

doi:10.1001/archinte.160.14.2219

Cited by 5 publications

(2 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The reason is that we assume that physicians in these areas are more likely to institute antibiotic treatment before admission to hospital due to the prolonged transportation time, than on-call physicians in areas nearer to hospitals. Institution of oral antibiotic treatment before admission to hospital has been shown to reduce risk of death and complications from MD in some studies [28][29][30][31][32]. On the other hand, a Danish study found an increased risk of death from MD in patients who received pre-hospital parenteral antibiotic treatment [33].…”

Section: Discussionmentioning

confidence: 99%

Morbidity, mortality and spatial distribution of meningococcal disease, 1974–2007

et al. 2009

View full text Add to dashboard Cite

To identify determinants for mortality and sequelae and to analyse the spatial distribution of meningococcal disease, we linked four national Danish registries. In the period 1974-2007, 5924 cases of meningococcal disease were registered. Our analysis confirms known risk factors for a fatal meningococcal disease outcome, i.e. septicaemia and high age (>50 years). The overall case-fatality rate was 7.6%; two phenotypes were found to be associated with increased risk of death; C:2a:P1.2,5 and B:15:P1.7,16. B:15:P1.7,16 was also associated with excess risk of perceptive hearing loss. The incidence rates of meningococcal disease were comparable between densely and less densely populated areas, but patients living further from a hospital were at significantly higher risk of dying from the infection. To improve control of meningococcal disease, it is important to understand the epidemiology and pathogenicity of virulent 'successful clones', such as C:2a:P1.2,5 and B:15:P1.7,16, and, eventually, to develop vaccines against serogroup B.

show abstract

Section: Discussionmentioning

confidence: 99%

Morbidity, mortality and spatial distribution of meningococcal disease, 1974–2007

et al. 2009

View full text Add to dashboard Cite

show abstract

“…With the results obtained, plasma DD levels have low sensitivity as a discriminant parameter between PE and pneumonia. These data and others [30, 31, 32]make it difficult to recommend the DD test as a standard part of the pulmonary embolism diagnostic algorithm at the present time [22]. …”

Section: Discussionmentioning

confidence: 99%

Diagnostic Value of D Dimer in Pulmonary Embolism and Pneumonia

Castro

Pérez-Rodríguez²,

Montaner³

et al. 2001

Respiration

View full text Add to dashboard Cite

Background: Diagnosis of pulmonary embolism (PE) and its clear-cut differentiation with other entities of occasional similar presentation remains difficult in routine clinical practice. High plasmatic levels of D dimer (DD), a specific fibrin derivate, have recently been reported in PE. Objective: The purpose of this study was to prospectively evaluate the diagnostic value of plasmatic DD in a clinical setting. Methods: We studied 52 patients with PE proven with pulmonary scintigraphic studies in relation to 19 patients posteriorly diagnosed of having community-acquired pneumonia and 30 healthy subjects. Evolution of DD levels whilst the patients were on intravenous anticoagulant therapy was evaluated by measuring DD concentration on admission and on day 7 in 10 patients. Results: Plasma DD levels were significantly higher in PE in relation to controls (p < 0.001). DD levels were also higher in patients diagnosed with community-acquired pneumonia in relation to controls (p < 0.05) but lower than those obtained in high probability PE (p < 0.05). Sensitivity and specificity of plasmatic DD in the emergency diagnosis of PE are of 92 and 71%, respectively. Plasma levels of DD were found to progressively decrease during the first week of heparin therapy, but they remained higher than in control subjects. Conclusions: Plasma DD levels are increased in patients with suspected PE and the degree of elevation is related to the results obtained in scintiscans. Moreover, DD concentrations progressively decrease during the first week of anticoagulant therapy. The increased DD levels found in patients with pneumonia make this test useless in the differential diagnosis between these two clinical entities.

show abstract

Current Awareness

2000

Pharmacoepidemiology and Drug

View full text Add to dashboard Cite

In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of pharmacoepidemiology and drug safety. Each bibliography is divided into 19 sections: 1 Books, Reviews & Symposia; 2 General; 3 Anti‐infective Agents; 4 Cardiovascular System Agents; 5 CNS Depressive Agents; 6 Non‐steroidal Anti‐inflammatory Agents; 7 CNS Agents; 8 Anti‐neoplastic Agents; 9 Haematological Agents; 10 Neuroregulator‐Blocking Agents; 11 Dermatological Agents; 12 Immunosuppressive Agents; 13 Autonomic Agents; 14 Respiratory System Agents; 15 Neuromuscular Agents; 16 Reproductive System Agents; 17 Gastrointestinal System Agents; 18 Anti‐inflammatory Agents ‐ Steroidal; 19 Others. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted.

show abstract

On Meningococcal Disease, Its Prognosis, and Undernotification of the Public Health Service

Cited by 5 publications

References 8 publications

Morbidity, mortality and spatial distribution of meningococcal disease, 1974–2007

Morbidity, mortality and spatial distribution of meningococcal disease, 1974–2007

Diagnostic Value of D Dimer in Pulmonary Embolism and Pneumonia

Current Awareness

Contact Info

Product

Resources

About