Some works of literature reported that fucoxanthin has diverse potential benefits for human health. Thus, this review would explain the sources of fucoxanthin, extraction techniques, bioactivities, and its potential application in Nutra- and cosmeceutical industries. Brown algae, such as Padina australis, Undaria pinnatifida; and the microalgae, such as Chaetoceros gracilis, Phaeodactylum tricornutum were sources of fucoxanthin. Then, the chemical structure of this xanthophyll is unique and that confers its biological activities. And then, the extraction process of fucoxanthin from macro- and microalgae is more safe, accessible, and economic, although this xanthophyll can be synthesized chemically. Generally, there are two techniques for the extraction of fucoxanthin, namely liquid solvent (conventional), and supercritical carbon dioxide (non-conventional) extractions. Furthermore, there are some bioactivities of fucoxanthin, including its activities of anticancer, antidiabetic, antiobesity, antioxidant; protective effects of skin, bone, and eyes. Based on in vivo assay of the animal, it has no adverse effects of fucoxanthin supplementation. Therefore, this xanthophyll might be applied in both the Nutra- and cosmeceutical industries. In the future, fucoxanthin and its derivatives would be important for human health, contributing to the beauty industry, and playing an important in the prevention of cancer and the disease related to lifestyle.