On-site airborne pathogen detection for infection risk mitigation

Qiu, Guangyu; Zhang, Xiaole; deMello, Andrew J.; Yao, Maosheng; Cao, Junji; Wang, Jing

doi:10.1039/d3cs00417a

Chem. Soc. Rev.

2023

DOI: 10.1039/d3cs00417a

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On-site airborne pathogen detection for infection risk mitigation

Guangyu Qiu,

Xiaole Zhang,

Andrew J. deMello

et al.

Abstract: The framework for on-site airborne pathogen detection and transmission risk mitigation.

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Cited by 12 publications

References 368 publications

(658 reference statements)

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Unsupervised Learning‐Assisted Acoustic‐Driven Nano‐Lens Holography for the Ultrasensitive and Amplification‐Free Detection of Viable Bacteria

Zhou,

Zhao,

Wen

et al. 2024

Advanced Science

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Bacterial infection is a crucial factor resulting in public health issues worldwide, often triggering epidemics and even fatalities. The accurate, rapid, and convenient detection of viable bacteria is an effective method for reducing infections and illness outbreaks. Here, an unsupervised learning–assisted and surface acoustic wave–interdigital transducer‐driven nano‐lens holography biosensing platform is developed for the ultrasensitive and amplification‐free detection of viable bacteria. The monitoring device integrated with the nano‐lens effect can achieve the holographic imaging of polystyrene microsphere probes in an ultra‐wide field of view (∽28.28 mm2), with a sensitivity limit of as low as 99 nm. A lightweight unsupervised learning hologram processing algorithm considerably reduces training time and computing hardware requirements, without requiring datasets with manual labels. By combining phage–mediated viable bacterial DNA extraction and enhanced CRISPR–Cas12a systems, this strategy successfully achieves the ultrasensitive detection of viable Salmonella in various real samples, demonstrating enhanced accuracy validated with the qPCR benchmark method. This approach has a low cost (∽$500) and is rapid (∽1 h) and highly sensitive (∽38 CFU mL−1), allowing for the amplification‐free detection of viable bacteria and emerging as a powerful tool for food safety inspection and clinical diagnosis.

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Unsupervised Learning‐Assisted Acoustic‐Driven Nano‐Lens Holography for the Ultrasensitive and Amplification‐Free Detection of Viable Bacteria

Zhou,

Zhao,

Wen

et al. 2024

Advanced Science

View full text Add to dashboard Cite

show abstract

Sources, compositions, spatio-temporal distributions, and human health risks of bioaerosols: A review

Feng,

Xu,

Yao

et al. 2024

Atmospheric Research

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Gel-confined fabrication of fully bio-based filtration membrane for green capture and rapid detection of airborne microbes

Yan,

Liu,

Liu

et al. 2024

Journal of Colloid and Interface Science

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On-site airborne pathogen detection for infection risk mitigation

Abstract: The framework for on-site airborne pathogen detection and transmission risk mitigation.

Cited by 12 publications

References 368 publications

Unsupervised Learning‐Assisted Acoustic‐Driven Nano‐Lens Holography for the Ultrasensitive and Amplification‐Free Detection of Viable Bacteria

Unsupervised Learning‐Assisted Acoustic‐Driven Nano‐Lens Holography for the Ultrasensitive and Amplification‐Free Detection of Viable Bacteria

Sources, compositions, spatio-temporal distributions, and human health risks of bioaerosols: A review

Gel-confined fabrication of fully bio-based filtration membrane for green capture and rapid detection of airborne microbes

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