On the accuracy, sensitivity, and grading of mouthrinse active matrix metalloproteinase‐8 (aMMP‐8) point‐of‐care testing (POCT)

Sorsa, Timo; Grigoriadis, Andreas; Sakellari, Dimitra; Gupta, Shipra; Sahni, Vaibhav; Tervahartiala, Taina; Räisänen, Ismo T.

doi:10.1111/jcpe.13521

Cited by 13 publications

(10 citation statements)

References 28 publications

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“…Recently, regarding chronic adult periodontitis, two distinct studies addressing the implementation of an aMMP‐8 chairside test as the key chairside biomarker in the new staging and grading classification of periodontitis have yielded varied results (Sorsa et al 2020 , 2021 ). Careful comparison of the clinical status and data of the patient materials involved in these two cohort studies revealed that Deng et al's ( 2021 ) cohort exerted clearly lesser gingivitis cases with lower Gingiva Index (GI) and, that is, with less deep PPD and less increased BOP% values (Deng et al, 2021 ) than the ones in the Sorsa et al's cohort (Sorsa et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Implementing of aMMP‐8 point‐of‐care test with a modified new disease classification in Finnish adolescent cohorts

Heikkinen

Raivisto²,

Räisänen

et al. 2022

Clinical & Exp Dental Res

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Objectives: Periodontitis is a multifactorial biofilm-induced inflammatory disease; however, clinical and radiographic information reflects events that have already occurred. aMMP-8 lateral-flow chairside or point-of-care-test (POC-test) results have also come to complement the overall status of the patient's current situation. The current study aimed to clarify the usefulness of aMMP-8 chairsidetest (aMMP-8 POCT) results to alert the initial or early periodontitis in adolescents, a potential periodontitis risk group with cut off 20 ng/ml in Stage I periodontitis, according to the current periodontitis classification system.Material and Methods: A total of 117 adolescents were aMMP-8 POC tested for aMMP-8 levels and examined for the full mouth and were interviewed for questions concerning health behavior.Results: Of all 117 participants, N = 38 (32.5%) was aMMP-8 POCT positive, and N = 34 (29.1%) had at least one 4 mm periodontal deepened pocket; however, only N = 16 (13.7%) had both characteristics. The subclinical stage (N = 47) could not be classified either as gingivitis or Stage I. Of the participants, who did not have any deepened periodontal pockets, 18 tested negative.Conclusions: Stage I is preceded by antecedent stages that should be tackled by oral healthcare prevention and personalized treatment modalities by professionals. Elevated (>20 ng/ml), positive aMMP-8 POCT results can be regarded as initial alarmer such as emerging risk. This should be utilized in the preventive personalized interventions by oral health professionals.

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Section: Discussionmentioning

confidence: 99%

Implementing of aMMP‐8 point‐of‐care test with a modified new disease classification in Finnish adolescent cohorts

Heikkinen

Raivisto²,

Räisänen

et al. 2022

Clinical & Exp Dental Res

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“…Early diagnosis of periodontitis in the group of infertile patients would enable treatment on time, leading to the elimination of inflammatory stimuli. The papers published after the adoption of the new classification of periodontitis in 2018 (27) considered the rapid test for aMMP-8 from oral mouth rinse, as used in present research, a key marker for early diagnosis and monitoring disease activity consistent with the new classification (32,33).…”

Section: Raspravamentioning

confidence: 99%

“…Rana dijagnoza parodonititsa, kad je riječ o neplodnim pacijenticama, omogućila bi pravodobnu terapiju i eliminaciju upalnih žarišta. U radovima objavljenima nakon prihvaćanja nove klasifikacije parodontitisa 2018. godine (27) predlaže se brzi test za aMMP8 iz ispirka usne šupljine, kakav je korišten i u ovom istraživanju, kao ključni biljeg za ranu dijagnozu i praćenje aktivnosti bolesti koja je u skladu s novom klasifikacijom (32,33). Prema našim rezultatima, osjetljivost i specifičnost testa za detekciju parodontitisa u skupini neplodnih pacijentica iznosila je 84 i 72 %, u skupini plodnih pacijentica 88 i 68 % te 86 i 70 % u ukupnoj populaciji pacijentica.…”

Section: Raspravaunclassified

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2022

Acta Stomatol Croat

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Dijagnostička točnost sline neplodnih žena dobivena testom aMMP-8 i analiza nalaza krvi UvodParodontitis, kronična upalna bolest potpornoga tkiva zuba, prije je bila povezana s nepovoljnim ishodima trudnoće (1), posebice manjom porođajnom težinom, prijevremenim porođajem i povećanim rizikom od preeklampsije u trudnica (2 -5). No, važno je istaknuti da je snaga te povezanosti ograničena pa su potrebna daljnja istraživanja. Literaturni podatci također povezuju parodontitis s kasnijim začećem i problemima s muškom i ženskom plodnošću (1, 6, 7). Neki su autori izvijestili o lošijem parodontnom statusu neplod-ACTA STOMATOLOGICA CROATICA www.ascro.hr

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“…An active MMP‐8 (aMMP‐8) point‐of‐care (PoC) test, has been validated across countries in both the adolescent and adult populations as a tool to define active and inactive sites of periodontal disease, evaluate prognosis, and assess patients during the treatment and maintenance phases (Alassiri et al, 2018 ; Heikkinen et al, 2016 ; Izadi Borujeni et al, 2015 ; Johnson et al, 2016 ; Lähteenmäki et al, 2020 ; Leppilahti et al, 2018 ; Lorenz et al, 2017 ; Nwhator et al, 2014 ; Räisänen et al, 2018 , 2019 ; Sorsa et al, 2020 , Sorsa, Grigoriadis et al, 2021 ). This PoC testing methodology, in particular, exhibits a sensitivity of 76%–83% and specificity of 96% with results being reported in a time frame of 5–7 min (Sorsa et al, 2015 , 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Validation of a noninvasive aMMP‐8 point‐of‐care diagnostic methodology in COVID‐19 patients with periodontal disease

Gupta

Mohindra

Singla

et al. 2022

Clinical & Exp Dental Res

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Objectives The aim of this study was to validate an active matrix metalloproteinase (MMP‐8) point‐of‐care diagnostic tool in COVID‐19 patients with periodontal disease. Subjects, Materials, and Methods Seventy‐two COVID‐19‐positive and 30 COVID‐19‐negative subjects were enrolled in the study. Demographic data were recorded, periodontal examination carried out, and chairside tests run for evaluating the expression of active MMP‐8 (aMMP‐8) in the site with maximum periodontal breakdown via gingival crevicular fluid sampling as well as via a mouth rinse‐based kit for general disease activity. In COVID‐19‐positive patients, the kits were run again once the patients turned COVID‐19 negative. Results The overall (n = 102) sensitivity/specificity of the mouthrinse‐based kits to detect periodontal disease was 79.41%/36.76% and that of site‐specific kits was 64.71%/55.88% while adjusting for age, gender, and smoking status increased the sensitivity and specificity (82.35%/76.47% and 73.53%/88.24, respectively). Receiver operating characteristic (ROC) analysis for the adjusted model revealed very good area under the ROC curve 0.746–0.869 (p < .001) and 0.740–0.872 (p < .001) (the aMMP‐8 mouth rinse and site‐specific kits, respectively). No statistically significant difference was observed in the distribution of results of aMMP‐8 mouth rinse test (p = .302) and aMMP‐8 site‐specific test (p = .189) once the subjects recovered from COVID‐19. Conclusions The findings of the present study support the aMMP‐8 point‐of‐care testing (PoCT) kits as screening tools for periodontitis in COVID‐19 patients. The overall screening accuracy can be further increased by utilizing adjunctively risk factors of periodontitis. The reported noninvasive, user‐friendly, and objective PoCT diagnostic methodology may provide a way of stratifying risk groups, deciding upon referrals, and in the institution of diligent oral hygiene regimens.

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On the accuracy, sensitivity, and grading of mouthrinse active matrix metalloproteinase‐8 (aMMP‐8) point‐of‐care testing (POCT)

Abstract: To the Editor, Active matrix metalloproteinase-8 (aMMP-8), used in point-of-care testing (POCT), can be regarded as a potential biomarker for peri-

Cited by 13 publications

References 28 publications

Implementing of aMMP‐8 point‐of‐care test with a modified new disease classification in Finnish adolescent cohorts

Implementing of aMMP‐8 point‐of‐care test with a modified new disease classification in Finnish adolescent cohorts

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Validation of a noninvasive aMMP‐8 point‐of‐care diagnostic methodology in COVID‐19 patients with periodontal disease

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