On the Binding of Benz[a]pyrene to DNA “in vivo”

Abstract

The Possibility that “in vivo” a binding takes place between DNA and benz [a] pyrene was examined. After oral administration of 3H-benz [a] pyrene, radioactive DNA was isolated from the skin, spleen and liver of NCLmice, and especially from the liver. This suggest that covalent binding between DNA and benz [a] pyrene takes place.