On the edge between organic solvent nanofiltration and ultrafiltration: Characterization of regenerated cellulose membrane with aspect on dendrimer purification and recycling

Krupková, Alena; Müllerová, Monika; Petričkovič, Roman; Strašák, Tomáš

doi:10.1016/j.seppur.2023.123141

Cited by 13 publications

(5 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Except for benzoate, all of the anions can be transferred back to the aqueous environment, leaving the free 8 in the chloroform layer (Figure S48). Benzoate stays in the complex even after three cycles of re-extraction and must be separated from the complex by nanofiltration of the mixture with methanol washing …”

Section: Resultsmentioning

confidence: 99%

“…Benzoate stays in the complex even after three cycles of re-extraction and must be separated from the complex by nanofiltration of the mixture with methanol washing. 43 Computational Studies. To gain some insight into the behavior of the anions at the water−chloroform interface in the presence of 7 and 8, we performed a series of molecular dynamic simulations 44 in three different conditions: (1) using dry chloroform as a solvent, (2) using chloroform with only a few water molecules (wet chloroform), and (3) using chloroform and enough water to create an extensive interface between the two phases.…”

Section: ■ Introductionmentioning

confidence: 99%

See 1 more Smart Citation

An Insight into Anion Extraction by Amphiphiles: Hydrophobic Microenvironments as a Requirement for the Extractant Selectivity

Salvadori,

Onali,

Mathez

et al. 2023

ACS Omega

View full text Add to dashboard Cite

Coupling of electron-deficient urea units with aliphatic chains gives rise to amphiphilic compounds that bind to phosphate and benzoate anions in the hydrogen bonding competitive solvent (DMSO) with K Ass = 6 580 M–1 and K Ass = 4 100 M–1, respectively. The anchoring of these receptor moieties to the dendritic support does not result in a loss of anion binding and enables new applications. Due to the formation of a microenvironment in the dendrimer, the high selectivity of the prepared compound toward benzoate is maintained even in the presence of aqueous media during extraction experiments. In the presence of binding sites at 5 mM concentration, the amount of benzoate corresponding to the full binding site occupancy is transferred into the chloroform phase from its 10 mM aqueous solution. A thorough investigation of the extraction behavior of the dendrimer reported here, supported by a series of molecular dynamics simulations, provides new insight into the fundamental principles of extraction of inorganic anions by amphiphiles.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

An Insight into Anion Extraction by Amphiphiles: Hydrophobic Microenvironments as a Requirement for the Extractant Selectivity

Salvadori,

Onali,

Mathez

et al. 2023

ACS Omega

View full text Add to dashboard Cite

show abstract

“…The procedure was repeated as necessary; three to four cycles were typically sufficient to obtain analytically pure products. 60 2.2. Production of Human Galectins.…”

Section: Methodsmentioning

confidence: 99%

“…1 H NMR was used to monitor the purification progress. The procedure was repeated as necessary; three to four cycles were typically sufficient to obtain analytically pure products …”

Section: Methodsmentioning

confidence: 99%

“…Then, we took advantage of a substantial size difference between the reaction components and purified the G n -A-AcLac 2m and G n -B-AcLac 2m by OSN. 59,60 For the final Odeacetylation step, we used triethylamine-catalyzed deacetylation under microwave irradiation 70 as this method accelerates the deprotection process. The disappearance of seven acetyl group singlets around 2.0 ppm in 1 Even though series A and B differ only in the triazole ring position, we observed subtle differences in NMR spectra demonstrating the structural features of both series.…”

Section: Synthesis and Characterization Of Lac-cs-ddmsmentioning

confidence: 99%

See 1 more Smart Citation

Lactose-Functionalized Carbosilane Glycodendrimers Are Highly Potent Multivalent Ligands for Galectin-9 Binding: Increased Glycan Affinity to Galectins Correlates with Aggregation Behavior

Müllerová,

Hovorková,

Závodná

et al. 2023

Biomacromolecules

Self Cite

View full text Add to dashboard Cite

Galectins, the glycan binding proteins, and their respective carbohydrate ligands represent a unique fundamental regulatory network modulating a plethora of biological processes. The advances in galectin-targeted therapy must be based on a deep understanding of the mechanism of ligand−protein recognition. Carbosilane dendrimers, the well-defined and finely tunable nanoscaffolds with low toxicity, are promising for multivalent carbohydrate ligand presentation to target galectin receptors. The study discloses a synthetic method for two types of lactosefunctionalized carbosilane glycodendrimers (Lac-CS-DDMs). Furthermore, we report their outstanding, dendritic effect-driven affinity to tandem-type galectins, especially Gal-9. In the enzymelinked immunosorbent assay, the affinity of the third-generation multivalent dendritic ligand bearing 32 lactose units to Gal-9 reached nanomolar values (IC 50 = 970 nM), being a 1400-fold more effective inhibitor than monovalent lactose for this protein. This demonstrates a game-changing impact of multivalent presentation on the inhibitory effect of a ligand as simple as lactose. Moreover, using DLS hydrodynamic diameter measurements, we correlated the increased affinity of the glycodendrimer ligands to Gal-3 and Gal-8 but especially to Gal-9 with the formation of relatively uniform and stable galectin/Lac-CS-DDM aggregates.

show abstract

Basic Properties of Solvents

2024

Handbook of Solvents, Volume 1

View full text Add to dashboard Cite

On the edge between organic solvent nanofiltration and ultrafiltration: Characterization of regenerated cellulose membrane with aspect on dendrimer purification and recycling

Cited by 13 publications

References 45 publications

An Insight into Anion Extraction by Amphiphiles: Hydrophobic Microenvironments as a Requirement for the Extractant Selectivity

An Insight into Anion Extraction by Amphiphiles: Hydrophobic Microenvironments as a Requirement for the Extractant Selectivity

Lactose-Functionalized Carbosilane Glycodendrimers Are Highly Potent Multivalent Ligands for Galectin-9 Binding: Increased Glycan Affinity to Galectins Correlates with Aggregation Behavior

Basic Properties of Solvents

Contact Info

Product

Resources

About