On the Effect of Planetary Stable Isotope Compositions on Growth and Survival of Terrestrial Organisms

Xie, Xueshu; Zubarev, Roman A.

doi:10.1371/journal.pone.0169296

Cited by 13 publications

(12 citation statements)

References 28 publications

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“…We found that long-term DDW consumption by DIO rats normalized the activities of the antioxidant enzymes SOD and CAT. This observation is consistent with previous data regarding the protective effect of DDW on the antioxidant system of the body in various pathologies [18,20,26,50,64,65].…”

Section: Discussionsupporting

confidence: 93%

“…Our data may not be related to the DDW factor until an exact mechanism of action has been described. However, the effect of deuterium on the change of biochemical parameters values is of interest to the scientific community [13][14][15][16]25,32,47,50,56,57,64,77] et al Therefore, our data will contribute to the study of mechanisms of action in this problem. The data obtained can be used in biomedical and therapeutic research, where deuterium can be considered as an adjuvant regulator of biological processes in the obesity model.…”

Section: Discussionmentioning

confidence: 99%

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Deuterium-Depleted Water as Adjuvant Therapeutic Agent for Treatment of Diet-Induced Obesity in Rats

et al. 2019

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In this study, we present the potential application of deuterium-depleted water (DDW) for the prevention and adjuvant treatment of obesity in rats. We tested the hypothesis that DDW can alleviate diet-induced obesity (DIO) and its associated metabolic impairments. Rats fed a high-fat diet had an increased body weight index (BWI), glucose concentration, and level of certain proinflammatory cytokines; decreased levels of insulin in the serum; decreased tryptophan and serotonin in the brain, and a decreased concentration of some heavy metals in the liver. Drinking DDW at a concentration of 10 ppm deuterium/protium (D/H) ad libitum for 3 weeks restored the BWI, glucose (serum), tryptophan (brain), and serotonin (brain) levels and concentration of Zn in the liver in the DIO animals to those of the controls. The levels of proinflammatory cytokines (IL-1β, IL-6, IFNγ) and anti-inflammatory TNFα were decreased in DIO rats, while anti-inflammatory cytokine (IL-4, IL-10) levels remained at the control levels, which is indicative of a pathophysiological syndrome. In contrast, in groups of rats treated with DDW, a significant increase in anti-inflammatory (IL-4, IL-10) and proinflammatory cytokines (IFNγ) was observed. This finding indicates a reduction in systemic inflammation in obese animals treated with DDW. Similarly, the high-fat diet caused an increased level of oxidative stress products, which was accompanied by decreased activity of both superoxide dismutase and catalase, whereas the administration of DDW decreased the level of oxidative stress and enhanced antioxidant enzyme activities.Molecules 2020, 25, 23 2 of 15 the development of new, safer and more effective pharmaceutical approaches for obesity treatment is essential.Natural water is a mixture of molecules containing stable isotopes 16 O, 17 O, 18 O, 1 H, and 2 H. The ratio of deuterium atoms to protium (D/H) in fresh and marine water is 132-156 µg/g (ppm) [7,8].Since the mass of protium H is half of the mass of deuterium D, effects arising from the replacement of isotopes influence biological systems; for example, the rates of chemical reactions between substances containing these isotopes may differ by a factor of 5-10 [9-11].Numerous publications over the last 20 years have been devoted to the study of the role of deuterium in natural (150 ppm) or reduced content in the human body [12]. It has been shown that deuterium-depleted water (DDW) exhibits antidotal properties with individual and combined effects on the dosage of pharmaceutical substances and auxiliary substances [13][14][15][16]. The mechanisms of such influence are due to the structure, physicochemical properties of DDW [17] and changes in ligand-receptor interactions in biological objects of different hierarchical levels [18]. DDW increases the rate of photosynthesis and promotes the growth of plants and aquatic animals [19,20]. In Europe, the USA, Japan, China and Russia, DDW is used for prophylactic and therapeutic purposes [21,22]. Currently, DDW is using as an adjuvant in cancer treatment ...

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Deuterium-Depleted Water as Adjuvant Therapeutic Agent for Treatment of Diet-Induced Obesity in Rats

et al. 2019

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“…Different D/H ratio is manifested in the form of kinetic isotope effect, which is characterized by a change in the biotransformation and excretion rates of the drugs [35][36][37] . Moreover, the methodological approaches for drugs quality control based on water isotopology, could reduce the toxic load of the body 38,39 .…”

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confidence: 99%

Effect of the deuterium on efficiency and type of adipogenic differentiation of human adipose-derived stem cells in vitro

Zlatska

Vasyliev

Gordiienko

et al. 2020

Sci Rep

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In this study, we performed an adipogenic differentiation of human adipose-derived stem cells (ADSCs) in vitro with different deuterium content (natural, low and high) in the culture medium during differentiation process with parallel analysis of the gene expression, metabolic activity and cell viability/ toxicity. After ADSCs differentiation into adipocytes we have done the analysis of differentiation process efficiency and determined a type of resulting adipocytes (by morphology, gene expression, UCP1 protein detection and adipokine production analysis). We have found that high (5 × 10 5 ppm) deuterium content significantly inhibit in vitro adipogenic differentiation of human ADSCs compared to the groups with natural (150 ppm) and low (30 ppm) deuterium content. Importantly, protocol of differentiation used in our study leads to white adipocytes development in groups with natural (control) and high deuterium content, whereas deuterium-depleted differentiation medium leads to brown-like (beige) adipocytes formation. We have also remarked the direct impact of deuterium on the cellular survival and metabolic activity. Interesting, in deuterium depleted-medium, the cells had normal survival rate and high metabolic activity, whereas the inhibitory effect of deuterated medium on ADSCs differentiation at least was partly associated with deuterium cytotoxicity and inhibitory effect on metabolic activity. The inhibitory effect of deuterium on metabolic activity and the subsequent decrease in the effectiveness of adipogenic differentiation is probably associated with mitochondrial dysfunction. Thus, deuterium could be considered as an element that affects the substance chirality. These findings may be the basis for the development of new approaches in the treatment of obesity, metabolic syndrome and diabetes through the regulation of adipose-derived stem cell differentiation and adipocyte functions. In the 21st century, non-communicable diseases (NCD) like obesity, metabolic syndrome and type 2 diabetes mellitus (T2DM) became the main medical problems of the humanity 1-4. These diseases started in the Western world, but in parallel with the improving of human life standards, technological progress and the spread of the Western lifestyle also around the world. So, these diseases have become a global epidemic 5. Currently, although there remains a correlation between the level of economic development and the frequency of these diseases, they have ceased to be a medical problem in high-income countries, but also have become an urgent item for the low-income and middle-income countries 6. A characteristic feature of obesity, metabolic syndrome and T2DM is the defection of glucose and lipids metabolism, which is manifested in insulin resistance, impaired fasting glucose, dyslipidemia, high blood sugar, high serum triglycerides, imbalance of different types of lipoproteins in blood serum 7,8 .

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“…Since heavy isotopes of O are considered to be “biologically safe,” the discussion about stable isotope enrichment as a possible additional cause of CAPP inhibition effects on bacteria and tumor cell growth, will focus solely on 2 H.…”

Section: Resultsmentioning

confidence: 99%

Changes of ²H and ¹⁸O abundances in water treated with non‐thermal atmospheric pressure plasma jet

Mance

Geilmann

Brand

et al. 2017

Plasma Processes & Polymers

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We treated water samples with a non‐thermal atmospheric pressure plasma jet and pure gas flow. Stable isotope measurements of water samples were performed by cavity ring‐down spectroscopy. Both plasma and purged gas treated samples resulted enriched in 2H and 18O, contrary to untreated water. The enrichment is dominantly caused by evaporation under non‐equilibrium conditions. The combined effect of ventilation and heating by plasma jet is the most probable reason for higher enrichment with heavier species of plasma treated samples than the ones purged by gas.

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On the Effect of Planetary Stable Isotope Compositions on Growth and Survival of Terrestrial Organisms

Cited by 13 publications

References 28 publications

Deuterium-Depleted Water as Adjuvant Therapeutic Agent for Treatment of Diet-Induced Obesity in Rats

Deuterium-Depleted Water as Adjuvant Therapeutic Agent for Treatment of Diet-Induced Obesity in Rats

Effect of the deuterium on efficiency and type of adipogenic differentiation of human adipose-derived stem cells in vitro

Changes of ²H and ¹⁸O abundances in water treated with non‐thermal atmospheric pressure plasma jet

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On the Effect of Planetary Stable Isotope Compositions on Growth and Survival of Terrestrial Organisms

Cited by 13 publications

References 28 publications

Deuterium-Depleted Water as Adjuvant Therapeutic Agent for Treatment of Diet-Induced Obesity in Rats

Deuterium-Depleted Water as Adjuvant Therapeutic Agent for Treatment of Diet-Induced Obesity in Rats

Effect of the deuterium on efficiency and type of adipogenic differentiation of human adipose-derived stem cells in vitro

Changes of 2H and 18O abundances in water treated with non‐thermal atmospheric pressure plasma jet

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Changes of ²H and ¹⁸O abundances in water treated with non‐thermal atmospheric pressure plasma jet