On the Fatty Acids Essential in Nutrition. Iii

Burr, George O.; Burr, Mildred M.; Miller, Elmer S.

doi:10.1016/s0021-9258(18)76213-3

Cited by 122 publications

(6 citation statements)

References 8 publications

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“…The high C18:1 oil can be heated to a higher temperature without smoking, making it more suitable as a cooking oil compared with polyunsaturated fatty acids (PUFA) . PUFA, such as C18:2, are essential components in animal feed, but derived from plants only . Neither animals nor humans have the necessary desaturases to convert C18:1 into C18:2 and C18:3 …”

Section: Introductionmentioning

confidence: 99%

Correlations between Tocopherol and Fatty Acid Components in Germplasm Collections of Brassica Oilseeds

Hussain

Zhang

et al. 2012

J. Agric. Food Chem.

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To date, little is known about the correlations among the tocopherol (T) and fatty acid (FA) components in rapeseed oils. In the current study, a germplasm collection of landraces from the species Brassica juncea , Brassica rapa , and Brassica napus and a collection of low erucic acid (EA) breeding lines from B. napus were analyzed for FA and T contents. In the groups comprising landraces, the most notable correlation was the significantly positive one between α-T and the sum of C18:1 and C18:2, whereas neither positive correlations were found between α-T and C18:3 nor were positive correlations observed between α-T and very long chain FAs (VLCFA). Hardly any association between γ-T and FA components was observed, indicating the possible function of α-T beyond its antioxidant property. The complexity of correlation between T and FA components in Brassica oils may arise from the role of α-T in the FA metabolism of endoplasmic reticulum (ER).

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Section: Introductionmentioning

confidence: 99%

Correlations between Tocopherol and Fatty Acid Components in Germplasm Collections of Brassica Oilseeds

Hussain

Zhang

et al. 2012

J. Agric. Food Chem.

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“…They performed studies on rats fed a special fat-free diet and observed several deficits in animals, including skin problems and disorders leading to death. These animals' health status was improved after dietary administration of PUFAs-linoleic acid and α-linolenic acid [42][43][44].…”

Section: The Importance Of N-6 and N-3 Pufa In Humansmentioning

confidence: 96%

Effects of Dietary n–3 and n–6 Polyunsaturated Fatty Acids in Inflammation and Cancerogenesis

Liput

Lepczyński

Ogłuszka

et al. 2021

IJMS

142

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The dietary recommendation encourages reducing saturated fatty acids (SFA) in diet and replacing them with polyunsaturated fatty acids (PUFAs) n–3 (omega–3) and n–6 (omega–6) to decrease the risk of metabolic disturbances. Consequently, excessive n–6 PUFAs content and high n–6/n–3 ratio are found in Western-type diet. The importance of a dietary n–6/n–3 ratio to prevent chronic diseases is linked with anti-inflammatory functions of linolenic acid (ALA, 18:3n–3) and longer-chain n–3 PUFAs. Thus, this review provides an overview of the role of oxylipins derived from n–3 PUFAs and oxylipins formed from n–6 PUFAs on inflammation. Evidence of PUFAs’ role in carcinogenesis was also discussed. In vitro studies, animal cancer models and epidemiological studies demonstrate that these two PUFA groups have different effects on the cell growth, proliferation and progression of neoplastic lesions.

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“…However, it is imperative to note that not all absorbed dietary LA and ALA are available for elongation and desaturation processes, as a fraction of these fatty acids are utilized for generating the energy source ATP during the β-oxidation process. Therefore, a prolonged deficiency in LA and/or ALA can lead to severe consequences, often manifesting as clinical symptoms [528][529][530][531][532]. LA, specifically, serves as a critical substrate for the biosynthesis of arachidonic acid (AA) and adrenic acid, both of which play crucial roles in early brain development [533][534][535].…”

Section: Relative Functional Significance Of Polyunsaturated Fatty Acidsmentioning

confidence: 99%

Review of Eukaryote Cellular Membrane Lipid Composition, with Special Attention to the Fatty Acids

Ali,

Szabó

2023

IJMS

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Biological membranes, primarily composed of lipids, envelop each living cell. The intricate composition and organization of membrane lipids, including the variety of fatty acids they encompass, serve a dynamic role in sustaining cellular structural integrity and functionality. Typically, modifications in lipid composition coincide with consequential alterations in universally significant signaling pathways. Exploring the various fatty acids, which serve as the foundational building blocks of membrane lipids, provides crucial insights into the underlying mechanisms governing a myriad of cellular processes, such as membrane fluidity, protein trafficking, signal transduction, intercellular communication, and the etiology of certain metabolic disorders. Furthermore, comprehending how alterations in the lipid composition, especially concerning the fatty acid profile, either contribute to or prevent the onset of pathological conditions stands as a compelling area of research. Hence, this review aims to meticulously introduce the intricacies of membrane lipids and their constituent fatty acids in a healthy organism, thereby illuminating their remarkable diversity and profound influence on cellular function. Furthermore, this review aspires to highlight some potential therapeutic targets for various pathological conditions that may be ameliorated through dietary fatty acid supplements. The initial section of this review expounds on the eukaryotic biomembranes and their complex lipids. Subsequent sections provide insights into the synthesis, membrane incorporation, and distribution of fatty acids across various fractions of membrane lipids. The last section highlights the functional significance of membrane-associated fatty acids and their innate capacity to shape the various cellular physiological responses.

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On the Fatty Acids Essential in Nutrition. Iii

Cited by 122 publications

References 8 publications

Correlations between Tocopherol and Fatty Acid Components in Germplasm Collections of Brassica Oilseeds

Correlations between Tocopherol and Fatty Acid Components in Germplasm Collections of Brassica Oilseeds

Effects of Dietary n–3 and n–6 Polyunsaturated Fatty Acids in Inflammation and Cancerogenesis

Review of Eukaryote Cellular Membrane Lipid Composition, with Special Attention to the Fatty Acids

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