On the need for standardized reporting of photophysical parameters of in vitro photodynamic therapy studies

Dick, Madison; Jamal, Hunain; Liu, Yi Ran; Lilge, Lothar

doi:10.1016/j.pdpdt.2022.103263

Cited by 1 publication

(1 citation statement)

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“…The main issues that drove to downgrading were related to indirectness, since 5 articles did not evaluate the effects of KMP in all cell lines of the study, and imprecision, as 41 articles did not calculate and adopt IC 50 for treatments with KMP. IC 50 is the most widely used and informative measure of a compound/drug's efficacy, and its proper determination facilitates the development of useful methods for drug discovery and clinical tests [82]. Moreover, it allows a clear view of drug effects, and IC 50 at a low concentration is prone to cause lower systemic toxicity when given to patients for treatment [83].…”

Section: Risk Of Biasmentioning

confidence: 99%

The Anticancer Potential of Kaempferol: A Systematic Review Based on In Vitro Studies

de Morais,

de Oliveira,

Farias Morais

et al. 2024

Cancers

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Given the heterogeneity of different malignant processes, planning cancer treatment is challenging. According to recent studies, natural products are likely to be effective in cancer prevention and treatment. Among bioactive flavonoids found in fruits and vegetables, kaempferol (KMP) is known for its anti-inflammatory, antioxidant, and anticancer properties. This systematic review aims to highlight the potential therapeutic effects of KMP on different types of solid malignant tumors. This review was conducted following the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines. Searches were performed in EMBASE, Medline/PubMed, Cochrane Collaboration Library, Science Direct, Scopus, and Google Scholar. After the application of study criteria, 64 studies were included. In vitro experiments demonstrated that KMP exerts antitumor effects by controlling tumor cell cycle progression, proliferation, apoptosis, migration, and invasion, as well as by inhibiting angiogenesis. KMP was also able to inhibit important markers that regulate epithelial–mesenchymal transition and enhanced the sensitivity of cancer cells to traditional drugs used in chemotherapy, including cisplatin and 5-fluorouracil. This flavonoid is a promising therapeutic compound and its combination with current anticancer agents, including targeted drugs, may potentially produce more effective and predictable results.

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Section: Risk Of Biasmentioning

confidence: 99%