On the submicroscopic morphogenesis of parietal cell in the gastric gland of the human fetus

Nomura, Yasuo

doi:10.1007/bf00521194

Cited by 38 publications

(31 citation statements)

References 42 publications

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“…Ultrastructural differentiation in the renewal of parietal cells in adult animals seems to occur in the same manner as their differentiation in fetal development described by ARNOLD (1966) andNOMURA (1966). Primitive parietal cells, having long, numerous microvilli in their apex, but no intracellular canaliculi, are located in the isthmus.…”

Section: Renewal Of Parietal Cellssupporting

confidence: 57%

Electron Microscopic Observations on Cell Proliferation and Differentiation in the Gastric Mucosa of the Mouse

Kataoka

1970

Arch. Histol. Jap., Arch. Histol. Jpn

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Section: Renewal Of Parietal Cellssupporting

confidence: 57%

Electron Microscopic Observations on Cell Proliferation and Differentiation in the Gastric Mucosa of the Mouse

Kataoka

1970

Arch. Histol. Jap., Arch. Histol. Jpn

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“…Thus, the close relationship between ultrastructural and functional differentiation of parietal cells previously observed in the rabbit (14,30) is also found in the rat. In man, typical gastric parietal cells have been observed from the fifth month of gestation (25), but the relatively high pH values observed at birth (1) does not allow to establish such a relationship.…”

Section: Discussionmentioning

confidence: 99%

“…Electron microscopic studies have shown that in some mammals species, including man, parietal cells of the gastric mucosa begin to develop during intrauterine life (14,15,25). It has been observed that gastric acid secretion takes place before birth in guinea pig (28), lamb (16), and rabbit (30).…”

Section: Speculationmentioning

confidence: 99%

Ontogenesis of Gastric Acid Secretion in Fetal Rat

Garzon¹,

Ducroc²,

Geloso³

1981

Pediatr Res

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Pediatr. Res. 15: 921-925 (1981) corticosteroids gastric acid development stomach fetus The pH of gastric fluid was measured in rat fetuses during the ANIMALS last 3 days of gestation. On day 19, the gastric pH was close to neutral. During the night of day 20, the pH was clearly lowered Sherman rats, fed a coinmercial diet (U.A.R., France), were (6.11 k 0.15 units), this decrease becoming more marked on the used for this study. To obtain fetuses of known age, females were following day. At birth (day 22), just before the first feeding, the mated overnight. Gestation was detected by palpation 2 wk later; pH of gastric fluid reached the mean value of 2.98 k 0.14 units. the day after the night of mating was considered as day zero of This drop in gastric pH was concomitant with an increase in gestation. In this strain, delivery occurs in the night of day 21. chloride concentration whereas the gastric Pcoz remained constant. These results imply that in term rat fetuses, the gastric CHEMICAL rnucosa secretes fixed acid, very likely hydrochloride acid. Ontogenesis of Gastric Acid Secretion in Fetal RatBERNARDThe administration of acetazolamide (inhibitor of carbonic anhydrase) to 20-day-old fetuses did not suppress the spontaneous acidification of gastric fluid, although the enzyme activity was reduced by approximately 80%. Moreover, the gastric pH in acetazolamide-injected fetuses was markedly lower than in the noninjected littermates. The administration of NaCl solution (acetazolamide vehicle) had no effect on the carbonic anhydrase activity but clearly decreased the pH of gastric fluid. Thus, the drop of gastric pH produced by injection of acetazolamide or saline solution alone probably results from a stress effect of puncture.In fetuses from adrenalectomized, metopirone-treated mothers, the injection of NaCl solution no longer had effect on the pH of gastric fluid whereas triamcinolone injection produced a clear decrease in the gastric pH 3 hr later. SpeculationCorticosteroids could play an important role in the development of H+ generation processes in parietal cells during the fetal period of life.Electron microscopic studies have shown that in some mammals species, including man, parietal cells of the gastric mucosa begin to develop during intrauterine life (14,15,25). It has been observed that gastric acid secretion takes place before birth in guinea pig (28), lamb (16), and rabbit (30). Newborn human infants have an intragastric pH ranging from 5.5 to 7; this pH then strongly decreases by 4 to 5 hr of age (1, 13). As far as we know, there is Acetazolamide was purchased from Theraplix (Paris, France), and triamcinolone was purchased from Sigma Chemical Co. (Saint Louis, MO). Metopirone was a gift of the Ciba laboratory, (Basel, Switzerland). EXPERIMENTAL PROCEDURESPregnant rats were adrenalectomized under ether anaesthesia on day 16 of gestation and then received 10 mg metopirone by intraperitoneal injections twice a day until the time of sacrifice. Such treatment suppresses, or at least strongly reduces, th...

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“…1966;Knospe, 1987]. In fetal tissue primitive oxyntic cells have been identified by means of their large cell size, the light cytoplasm, the richness in mitochondria, the occurrence of vesicular, vac uolar and tubular membrane profiles (Tuovinen, 1942;Nomura, 1966;Hayward. 1967a,b;Knospe, 1986] and the formation of long and slender apical microvilli [Arnold.…”

Section: The Ultrastructural Differentiation O F the Oxyntic Cellmentioning

confidence: 99%

“…In cat. oxyntic cell genesis is described to start in the second gestational trimester, while in man primitive oxyn tic cells have already been identified at the end of the first gestational trimester | Plenk, 1931;Utsuki 1956;Salenius, 1962: Nomura. 1966Aitchison and Brown.…”

Section: Introductionmentioning

confidence: 99%

Differentiation of Oxyntic Cells during Early Ontogenesis in the Bovine

Sommer¹,

Kressin²,

Schnorr³

1994

Cells Tissues Organs

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The origin and the differentiation of oxyntic cells in fetal bovine abomasum were investigated using transmission electron and light microscopic methods. In the oxyntic gland region oxyntic cell precursors and immature oxyntic cells appear as early as at the end of the first trimester of gestation – much earlier than described in any other mammalian animal species. Immature oxyntic cells are characterized by long apical microvilli, by their triangular-shaped light cytoplasm rich in large and numerous mitochondria, by the existence of vesicular profiles and by the incipient invagination of the apical plasma membrane forming a primitive intracellular canaliculus expanding into central areas of the cell. The oxyntic cell represents the first exocrine cell type developing from secretory granule-containing cells in the base of the primitive gastric glands.

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On the submicroscopic morphogenesis of parietal cell in the gastric gland of the human fetus

Cited by 38 publications

References 42 publications

Electron Microscopic Observations on Cell Proliferation and Differentiation in the Gastric Mucosa of the Mouse

Electron Microscopic Observations on Cell Proliferation and Differentiation in the Gastric Mucosa of the Mouse

Ontogenesis of Gastric Acid Secretion in Fetal Rat

Differentiation of Oxyntic Cells during Early Ontogenesis in the Bovine

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