Onchocerca-like lesions induced by the filarioid nematode<i>cercopithifilaria johnstoni,</i>in its natural hosts and in the laboratory rat

Vuong, P. N.; Spratt, David M.; Wanji, Samuel; Aimard, L.; Bain, O.

doi:10.1051/parasite/1993684176

Cited by 11 publications

(6 citation statements)

References 4 publications

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“…Monanema martini in rodents have suggested that the microfilariae could migrate through the lymphatic system of the skin [35], [36], [37]. Indeed, dermic microfilariae of Monanema martini in rodents and those of Cercopithifilaria johnstoni in rats [38] were evidenced in the lymphatic vessels of the skin and in deeper localisations [36], [39]. In our hand, we regularly observed microfilariae in close contact with the lymphatic endothelial lining of the dermis, often in perivascular spaces (Figure 4D) but not inside the lymphatic vessel.…”

Section: Discussionmentioning

confidence: 99%

Lymphatic Vascularisation and Involvement of Lyve-1+ Macrophages in the Human Onchocerca Nodule

Attout¹,

Hoerauf²,

Dénécé³

et al. 2009

PLoS ONE

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Onchocerciasis, caused by the filarial nematode Onchocerca volvulus, is a parasitic disease leading to debilitating skin disease and blindness, with major economic and social consequences. The pathology of onchocerciasis is principally considered to be a consequence of long-standing host inflammatory responses. In onchocerciasis a subcutaneous nodule is formed around the female worms, the core of which is a dense infiltrate of inflammatory cells in which microfilariae are released. It has been established that the formation of nodules is associated with angiogenesis. In this study, we show using specific markers of endothelium (CD31) and lymphatic endothelial cells (Lyve-1, Podoplanin) that not only angiogenesis but also lymphangiogenesis occurs within the nodule. 7% of the microfilariae could be found within the lymphatics, but none within blood vessels in these nodules, suggesting a possible route of migration for the larvae. The neovascularisation was associated with a particular pattern of angio/lymphangiogenic factors in nodules of onchocerciasis patients, characterized by the expression of CXCL12, CXCR4, VEGF-C, Angiopoietin-1 and Angiopoietin-2. Interestingly, a proportion of macrophages were found to be positive for Lyve-1 and some were integrated into the endothelium of the lymphatic vessels, revealing their plasticity in the nodular micro-environment. These results indicate that lymphatic as well as blood vascularization is induced around O. volvulus worms, either by the parasite itself, e.g. by the release of angiogenic and lymphangiogenic factors, or by consecutive host immune responses.

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Section: Discussionmentioning

confidence: 99%

Lymphatic Vascularisation and Involvement of Lyve-1+ Macrophages in the Human Onchocerca Nodule

Attout¹,

Hoerauf²,

Dénécé³

et al. 2009

PLoS ONE

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“…This phe nomenon was not specific to Molineus as it had also been noted in other parasitic diseases. (Vuong et al, 1993(Vuong et al, , 1994(Vuong et al, , 1996. With time, the inflammatory reac tion waned and the lesion underwent scarring.…”

Section: Histologymentioning

confidence: 99%

Molineus torulosus(Nematoda, Trichostrongylina, Molineoidea) a parasite of Neotropical primates: new morphological and histological data

2001

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“…This shows the potential for aberrant migration of this parasite. Voung et al ., using experimental laboratory rats infected with Cercopithifilaria johnstoni , induced ocular lesions similar to those described in human onchocerciasis. According to this study, dermal microfilariae live in the lymphatic vessels, but they may inadvertently arrive in the perivascular connective tissue causing an inflammatory reaction.…”

Section: Discussionmentioning

confidence: 56%

Keratitis due to microfilariae in dogs: a newly recognized disease

Morales¹,

Perlmann

Abelha³

et al. 2017

Veterinary Ophthalmology

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Parasitic agents have been associated with keratitis, but a diagnosis of parasitic keratitis has not been commonly made in domestic animals. The purpose of this study was to describe the clinical and histopathological findings in seven dogs with chronic keratitis caused by microfilariae diagnosed in Brazil. All dogs presented with superficial corneal opacities of varying degrees affecting the perilimbal and central regions of the cornea, with other opaque areas appearing as crystalline deposits and corneal vascularization. The lesions were bilateral and were associated with mild-to-moderate conjunctival hyperemia. There was no history of blepharospasm or pruritus, and no subjects presented with epithelial erosions. Corneal biopsy revealed free microfilariae in the corneal stroma, with varying degrees of inflammation and collagen fiber destruction. The microfilariae were also found in skin lesions by skin snip technique. No adult worms were found in these dogs, and no dogs were on heartworm preventative before diagnosis. Monthly doses of oral ivermectin improved ocular and dermal lesions. One dog showed complete remission with the treatment. The species of the microfilariae was not identified.

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Onchocerca-like lesions induced by the filarioid nematodecercopithifilaria johnstoni,in its natural hosts and in the laboratory rat

Cited by 11 publications

References 4 publications

Lymphatic Vascularisation and Involvement of Lyve-1+ Macrophages in the Human Onchocerca Nodule

Lymphatic Vascularisation and Involvement of Lyve-1+ Macrophages in the Human Onchocerca Nodule

Molineus torulosus(Nematoda, Trichostrongylina, Molineoidea) a parasite of Neotropical primates: new morphological and histological data

Keratitis due to microfilariae in dogs: a newly recognized disease

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