Oncogenic RAS Regulates Long Noncoding RNA <i>Orilnc1</i> in Human Cancer

Zhang, Dongmei; Zhang, Gao; Hu, Xiaowen; Wu, Lawrence W.; Feng, Yi; He, Sidan; Zhang, Youyou; Hu, Zhongyi; Yang, Lu; Tian, Tian; Xu, Weiting; Wei, Zhi; Lu, Yiling; Flaherty, Keith T.; Mills, Gordon B.; Gimotty, Phyllis A.; Xu, Xiaowei; Herlyn, Meenhard; Zhang, Lin

doi:10.1158/0008-5472.can-16-1768

Cited by 36 publications

(30 citation statements)

References 41 publications

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“…Orilnc1 was highly expressed in BRAF‐mutated cancers, such as melanoma, and regulated by RAS–RAF–MEK–extracellular signal‐regulated kinase (ERK) signaling via the transcription factor (activator protein 1 [AP1]). Silencing of Orilnc1 blocked tumor cell proliferation and growth in vitro and in vivo …”

Section: Lncrnas Involved In Uncontrolled Cancer Growthmentioning

confidence: 99%

Regulatory roles of long noncoding RNAs implicated in cancer hallmarks

Wang

Zhang

Chen

et al. 2019

Intl Journal of Cancer

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Cancer cells acquire numerous biological properties (designated “cancer hallmarks”), such as cell survival and energy metabolism, that facilitate tumor growth and metastatic dissemination during development. To date, eight hallmarks of cancer have been identified that provide a logical framework for understanding the remarkable diversity of neoplastic diseases, as proposed by Douglas Hanahan and Robert A. Weinberg. Long noncoding RNAs (lncRNAs), a category of transcripts widely demonstrated to exert significant regulatory effects on biological processes, have attracted considerable research attention due to their association with the occurrence and development of cancer. The mechanisms by which lncRNAs exert their functions require elucidation to optimize their potential utility as alternative biomarkers and therapeutic targets during tumor occurrence and progression. In this review, we have discussed recent research progress on lncRNAs involved in various cancer hallmarks and their related mechanisms of action, with a view to providing an updated picture of their immense therapeutic potential in the fight against cancer.

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Section: Lncrnas Involved In Uncontrolled Cancer Growthmentioning

confidence: 99%

Regulatory roles of long noncoding RNAs implicated in cancer hallmarks

Wang

Zhang

Chen

et al. 2019

Intl Journal of Cancer

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“…Lin et al [12] conducted experimental analysis of vacuum process for recycling of waste lead storage battery. Zhang et al [13] studied about the practices in secondary lead recycling technologies (Electrowinning) and development of sustainable greener recycling methods, such as Paste-to-Paste recycling and hydrogen-lead oxide fuel cell method. Chen et al [14] analysed the environmental impacts of lead acid batteries.…”

Section: Literature Reviewmentioning

confidence: 99%

“…The LABs are smelted in the furnace to produce antimonial lead bullion and soda slags or mattes. Many developments were done in this process which includes the utilization of different type of furnaces and preheating equipment [13]. Recent technological methods in the smelting process of LAB's are QSL process, Isasmelt Paste Smelting process, Kivcet method, Kaldo smelting process and Rotary or Reverberatory furnace smelting.…”

Section: Lead Acid Batteriesmentioning

confidence: 99%

Sustainable recycling technologies for Solar PV off-grid system

Uppal¹,

Tamboli²,

Wubhayavedantapuram³

2017

E3S Web Conf.

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Policy makers throughout the world have accepted climate change as a repercussion of fossil fuel exploitation. This has led the governments to integrate renewable energy streams in their national energy mix. PV off-grid Systems have been at the forefront of this transition because of their permanently increasing efficiency and cost effectiveness. These systems are expected to produce large amount of different waste streams at the end of their lifetime. It is important that these waste streams should be recycled because of the lack of available resources. Our study found that separate researches have been carried out to increase the efficiencies of recycling of individual PV system components but there is a lack of a comprehensive methodical research which details efficient and sustainable recycling processes for the entire PV off-grid system. This paper reviews the current and future recycling technologies for PV off-grid systems and presents a scheme of the most sustainable recycling technologies which have the potential for adoption. Full Recovery End-of-Life Photovoltaic (FRELP) recycling technology can offer opportunities to sustainably recycle crystalline silicon PV modules. Electro-hydrometallurgical process & Vacuum technologies can be used for recovering lead from lead acid batteries with a high recovery rate. The metals in the WEEE can be recycled by using a combination of biometallurgical technology, vacuum metallurgical technology and other advanced metallurgical technologies (utrasonical, mechano-chemical technology) while the plastic components can be effectively recycled without separation by using compatibilizers. All these advanced technologies when used in combination with each other provide sustainable recycling options for growing PV off-grid systems waste. These promising technologies still need further improvement and require proper integration techniques before implementation.

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“…KCNQ1OT1 was reported to promote melanoma growth and metastasis . Silencing of lncRNA Orilnc1 was shown to block melanoma cell growth . LncRNA SPRIGHTLY was identified to facilitate cancer‐related gene expression in melanoma .…”

Section: Introductionmentioning

confidence: 99%

“…26 Silencing of lncRNA Orilnc1 was shown to block melanoma cell growth. 27 LncRNA SPRIGHTLY was identified to facilitate cancerrelated gene expression in melanoma. 28 LncRNA NKILA was reported to inhibit the invasion-metastasis cascade of melanoma.…”

mentioning

confidence: 99%

Increased expression of long noncoding RNA GAS6‐AS2 promotes proliferation and inhibits apoptosis of melanoma cells via upregulating GAS6 expression

et al. 2019

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Long noncoding RNAs (lncRNAs) are frequently aberrantly expressed and involved in many cancers, including melanoma. GAS6‐AS2 was a recently identified cancer‐related lncRNA. However, the expression, roles, and functional mechanisms of GAS6‐AS2 in melanoma remain unknown. In this study, we found that lncRNA GAS6‐AS2 is significantly elevated in melanoma tissues and cells. Elevated expression of GAS6‐AS2 is positively correlated with advanced stages and poor prognosis in melanoma. Functional assays demonstrated that ectopic expression of GAS6‐AS2 promotes proliferation and inhibits apoptosis of melanoma cells. In contrast, knockdown of GAS6‐AS2 inhibits proliferation and promotes apoptosis of melanoma cells. Furthermore, in vivo functional assays showed that GAS6‐AS2 promotes melanoma xenograft growth. Mechanistically, we found that GAS6‐AS2 upregulates GAS6 expression, promotes GAS6 secretion, and activates AXL/AKT/ERK signals. The expression of GAS6 was positively correlated with that of GAS6‐AS2 in melanoma tissues. In addition, deficiency of GAS6 reverses the biological roles of GAS6‐AS2 overexpression in melanoma cell proliferation and apoptosis. Collectively, our data identified GAS6‐AS2 as an oncogenic lncRNA in melanoma via activation of GAS6/AXL/AKT/ERK signals. Our data suggested that GAS6‐AS2 may be a novel potential prognostic biomarker and therapeutic target for melanoma.

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Oncogenic RAS Regulates Long Noncoding RNA Orilnc1 in Human Cancer

Cited by 36 publications

References 41 publications

Regulatory roles of long noncoding RNAs implicated in cancer hallmarks

Regulatory roles of long noncoding RNAs implicated in cancer hallmarks

Sustainable recycling technologies for Solar PV off-grid system

Increased expression of long noncoding RNA GAS6‐AS2 promotes proliferation and inhibits apoptosis of melanoma cells via upregulating GAS6 expression

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