Oncogenic Wnt3a is a promising sensitive biomarker for monitoring hepatocarcinogenesis

Yao, Min; Wang, Jianjun; Chen, Xiyu; Sai, Wen-Li; Yang, Jie; Wang, Defeng; Wang, Li; Yao, Dengfu

doi:10.1016/j.hbpd.2022.11.004

Cited by 2 publications

(2 citation statements)

References 41 publications

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“… Abnormal activation of Wnt3a in hepatocarcinogenesis[ 49 , 53 , 56 , 57 , 61 ]. The Wnt/β-catenin signalling pathway contains 19 mammalian Wnt proteins.…”

Section: Wnt3a Signallingmentioning

confidence: 99%

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Early monitoring values of oncogenic signalling molecules for hepatocellular carcinoma

Yao,

Fang,

Xie

et al. 2024

World J Gastrointest Oncol

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The prevention and early diagnosis of liver cancer remains a global medical challenge. During the malignant transformation of hepatocytes, a variety of oncogenic cellular signalling molecules, such as novel high mobility group-Box 3, angiopoietin-2, Golgi protein 73, glypican-3, Wnt3a (a signalling molecule in the Wnt/β-catenin pathway), and secretory clusterin, can be expressed and secreted into the blood. These signalling molecules are derived from different signalling pathways and may not only participate in the malignant transformation of hepatocytes but also become early diagnostic indicators of hepatocarcinogenesis or specific targeted molecules for hepatocellular carcinoma therapy. This article reviews recent progress in the study of several signalling molecules as sensitive biomarkers for monitoring hepatocarcinogenesis.

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“… Abnormal activation of Wnt3a in hepatocarcinogenesis[ 49 , 53 , 56 , 57 , 61 ]. The Wnt/β-catenin signalling pathway contains 19 mammalian Wnt proteins.…”

Section: Wnt3a Signallingmentioning

confidence: 99%

“…A dynamic model of rat hepatocarcinogenesis was successfully established to investigate the alteration of Wnt3a and its monitoring value in early HCC[ 61 ]. Based on liver pathological examination with HE staining, the rats were divided into the NC, HD, PC and HCC groups.…”

Section: Wnt3a Signallingmentioning

confidence: 99%

Early monitoring values of oncogenic signalling molecules for hepatocellular carcinoma

Yao,

Fang,

Xie

et al. 2024

World J Gastrointest Oncol

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The mechanism of PDE7B inhibiting the development of hepatocellular carcinoma through oxidative stress

Luo,

Gao,

Zhao

et al. 2024

Front. Immunol.

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BackgroundLiver cancer presents a significant challenge to global health and is currently ranked as the sixth most common form of cancer worldwide. Recent research indicates that phosphodiesterases play a role in various physiological and pathological processes, with a specific focus on their impact on cancer advancement. There is a scarcity of studies investigating the function and mechanisms of phosphodiesterases in the development and progression of hepatocellular carcinoma (HCC).MethodsReal-time fluorescence quantitative polymerase chain reaction (qRT-PCR) and Western blotting were employed to analyze the expression of PDE7B in hepatocellular carcinoma tissues and cells. The biological role of PDE7B in HCC was investigated by both overexpressing and knocking down PDE7B in liver cancer cell lines. Furthermore, potential target proteins of PDE7B were identified through transcriptome sequencing.ResultsPDE7B is conspicuously reduced in tissues and cells of hepatocellular carcinoma, showing a connection with an unfavorable prognosis. Inhibiting PDE7B boosts the growth, movement, and infiltration of liver cancer cells, while its increased expression has the reverse impact. According to our trials relating to oxidative stress, PDE7B appears to control cell death in liver cancer cells by impacting the production of reactive oxygen species. Therefore, we propose that PDE7B could hinder the initiation and advancement of HCC through an oxidative stress pathway.ConclusionThe research we conducted reveals that PDE7B, a gene with minimal levels of activity in hepatocellular carcinoma, possesses the capacity to inhibit the proliferation, invasion, and migration of HCC cells. PDE7B can impact the development of hepatocellular carcinoma by adjusting mechanisms related to oxidative stress.

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Oncogenic Wnt3a is a promising sensitive biomarker for monitoring hepatocarcinogenesis

Cited by 2 publications

References 41 publications

Early monitoring values of oncogenic signalling molecules for hepatocellular carcinoma

Early monitoring values of oncogenic signalling molecules for hepatocellular carcinoma

The mechanism of PDE7B inhibiting the development of hepatocellular carcinoma through oxidative stress

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