Ondansetron, granisetron, and dexamethasone compared for the prevention of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy

Abstract

Prophylactic dexamethasone 8 mg i.v. significantly reduced the incidence of PONV in patients undergoing laparoscopic cholecystectomy. Dexamethasone 8 mg was as effective as ondansetron 4 mg and granisetron 3 mg, and it was more effective than placebo.

Practice Guidelines for Postanesthetic Care

“…Drugs evaluated by these Guidelines for the prophylaxis of nausea and vomiting include: (1) antihistamines, (2) 5-HT3 antiemetics, (3) tranquilizers/neuroleptics, (4) metoclopramide, (5) scopolamine, and (6) 2-6 granisetron (reduced vomiting), [7][8][9][10][11] ondansetron (reduced vomiting and rescue antiemetics), [7][8][9][12][13][14][15][16][17][18][19][20][21][22][23][24] and tropisetron (reduced vomiting and rescue antiemetics).…”

“…Meta-analyses of new double-blind RCTs comparing dexamethasone with placebo controls corroborate findings reported in the original Guidelines indicating that this antiemetic is effective in the prophylaxis of postoperative vomiting and reduced use of rescue antiemetics, and for the prophylaxis of nausea when higher doses are administered (Category A1-B evidence). 8,12,24,26,29,36,37,39,41,43,44,[47][48][49][50][51][52][53][54][55][56] The consultants and ASA members agree that the pharmacologic prophylaxis of nausea and vomiting improves patient comfort and satisfaction, reduces time to discharge, and should be done selectively. Multiple Pharmacologic Agents for Prophylaxis of Nausea and Vomiting.…”

Double-blind comparison of granisetron, promethazine, or a combination of both for the prevention of postoperative nausea and vomiting in females undergoing outpatient laparoscopies

“…Number in % or mean ± SD ASA American Society of Anesthesiologists; PONV postoperative nausea and vomiting; PACU postanesthesia care unit Granisetron and promethazine for preventing PONV 833 patients, Erhan et al 16 compared intravenous ondansetron 4 mg, granisetron 3 mg, or dexamethasone 8 mg with placebo. All active treatment groups were more effective than placebo.…”

A Comparative Study of Palonosetron and Palonosetron With Dexamethasone for Prophylaxis of Postoperative Nausea and Vomiting in Laparoscopic Cholecystectomy Under General Anaesthesia

“…There were some debates in relation to the dose of palonosetron 18 and dexamethasone 23 as the prophylaxis of PONV during our study. We considered using the dose of 0.075 mg palonosetron and 8 mg dexamethasone, as it was used most frequently in various previous studies.…”