One-dimensional chiral copper (II) complexes with novel nano-structures and superior antitumor activity

Abstract

Three novel copper(II) compounds of formulas {[Cu(Phen)(Ala)]·NO3·H2O}n (1), {[Cu(Phen)(Ala)]·NO3}n (2) and [Cu(Ala)2]n (3) have been synthesized and determined by X-ray diffraction. 1 and 2 are shown in one dimensional long-chain chiral structures, and 3 is a two dimensional checkerboard-type structure. Both 1 and 2 displayed a higher anticancer activity than 3 against various cancer cells, even higher than the similar mononuclear complexes and clinical anticancer drug 5-fluorouracil. The noncancerous cell lines (CCC-HEL-1) have showed that complexes 1-3 have hardly any cytotoxicity. Transmission electron microscopy was studied to show the nano-structure and π function of two complexes. The ligand 1,10-phenanthroline inserted into its enantiomer lead complex 1 stable, and the π-π interaction outside the chain made complex 2 active, which is easy to crack and pile up together. In addition, the energy gaps, UV-vis, luminescent and cyclic voltammetry were experimented to show the stable one dimensional long-chain chiral structure and the π function of two complexes.

Solvent effects on the crystallization and structure of ternary copper(ii) coordination compounds with l-threonine and 1,10-phenanthroline

“…These 98 data sets being published in 80 different articles show the lack of systematic exploration of the crystal structures and structure-property relationship of such copper( ii ) ternary coordination compounds. Only in two research articles different solvates of these ternary coordination compounds were investigated – monohydrate and unhydrated alaninato complexes [ 16 ] and six serinato solvates involving water and/or methanol [ 5 ]. Both described alaninato compounds are coordination polymers, where carboxylic group acts as bridge between two copper(II) atoms.…”

DNA binding and cleavage activity of three new copper (II) complexes of chiral N-salicyl-β-amino alcohol Schiff bases

“…The synthesis and design of chiral metal complexes have attracted a considerable amount of attention because they can bind to DNA, and changes their photophysical properties [1]. In previous work, DNA binding and cleavage studies of chiral copper complexes have been broadly investigated [14][15][16][17][18][19]; however, study on Schiff bases copper complexes with chiral amino-alcohols have rarely been reported [20][21][22][23].…”