One-for-All Intelligent Material for Triple-Modality Imaging-Guided Cancer Surgery

Gu, Danan; Zeng, Lefeng

doi:10.1016/j.chempr.2019.10.017

Cited by 4 publications

(2 citation statements)

References 7 publications

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“…Cancer is a major threat to human life and health. [1][2][3][4] There are various traditional methods for cancer treatment, including surgery, 5 chemotherapy, 6 and radiotherapy. 7,8 More than 90 percent of patients suffering from early-stage tumors can be cured by surgery and radiation.…”

Section: Introductionmentioning

confidence: 99%

Organelle-based immunotherapy strategies for fighting against cancer

Li,

Song,

Yin

et al. 2024

Chem. Commun.

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Section: Introductionmentioning

confidence: 99%

Organelle-based immunotherapy strategies for fighting against cancer

Li,

Song,

Yin

et al. 2024

Chem. Commun.

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“…Between these two strategies, for "all-in-one" formulation, it is not easy to program precisely their fabrication process [26] ; for "one-for-all" route, it seems to be more difficult to formulate the nanoagent itself. [29,30] Therefore, bridges (inherent logic) between imaging and treatment, as well as among various imaging modes, require careful rethinking, which restricts the practical effects of imaging-guided antitumor therapies. [31,32] Therefore, novel strategies to engineer NCs that match the requirements of imaging and further treatment are urgently needed.…”

Section: Introductionmentioning

confidence: 99%

Introducing Specific Iodine Ions in Perovskite‐Based Nanocomplex to Cater for Versatile Biomedical Imaging and Tumor Radiotherapy

Yue,

Xu,

Jiang

et al. 2023

Adv Healthcare Materials

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Multimodal biomedical imaging and imaging‐guided therapy have garnered extensive attention owing to the aid of nanoagents with the aim of further improving the therapeutic efficacy of diseases. The ability to engineer nanocomplexes (NCs) or control how they behave within an organism remains largely elusive. Here, a multifunctional nanoplatform is developed based on stabilized I‐doped perovskite, CsPbBr3‐xIx@SiO2@Lip‐c(RGD)2 (PSL‐c(RGD)2) NCs. In particular, by regulating the amount of regular I− ions introduced, the fluorescence emission spectrum of perovskite‐based NCs can be modulated well to match the requirement for biomedical optical imaging at the scale from molecule, cell to mouse; doping 125I enables the nanoformulation to be competent for single‐photon emission computed tomography (SPECT) imaging; the introduction of 131I− imparts the NCs with the capability for radiotherapy. Through facile manipulation of specific iodine ions, this nanoplatform exhibits a remarkable ability to match multifunctional biomedical imaging and tumor therapy. In addition, their in vivo behavior can be manipulated by adjusting the thickness of the silica shell and the surface polarity for more practical applications. These experimental explorations offer a novel approach for engineering desirable multimodal NCs to simultaneously image and combat malignant tumors.

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