One-Pot and Solvent Free Synthesis of 3,4-Dihydropyrimidin-2(1<i>H</i>)-Ones Using Recyclable Resin Purolite CT275DR as a Heterogeneous Catalyst via Three-Component Biginelli-Like Reactions

Shinde, Ravindra R.; Farooqui, Mazahar

doi:10.1080/10406638.2021.1984262

Polycyclic Aromatic Compounds

2021

DOI: 10.1080/10406638.2021.1984262

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One-Pot and Solvent Free Synthesis of 3,4-Dihydropyrimidin-2(1H)-Ones Using Recyclable Resin Purolite CT275DR as a Heterogeneous Catalyst via Three-Component Biginelli-Like Reactions

Ravindra R. Shinde¹,

Mazahar Farooqui²

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2023

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Novel Dihydropyrimidinones: Molecular Docking, Synthesis and Anti-Neoplastic Activity

Toraskar,

Chaure,

Sontakke

2023

ajc

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Recent years have showed great interest in the synthesis of pyrimidinone and its applications in medicinal chemistry. Chalcones were synthesized through the Claisen-Schmidt condensation reaction between substituted aldehydes and acetone in the presence of LiOH to produce dihydropyrimidinones, which were then subjected to urea treatment in the presence of strong HCl to give dihydropyrimidinone derivatives. The antiproliferative activity of synthesized components was screened against MCF7 and MCA-MB-231 cancer cell lines. Compound 4A1 was found to have promising anticancer activity against both cell lines. Overall, the approach makes it possible to synthesize dihydropyrimidinones with potential anticancer properties.

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Novel Dihydropyrimidinones: Molecular Docking, Synthesis and Anti-Neoplastic Activity

Toraskar,

Chaure,

Sontakke

2023

ajc

View full text Add to dashboard Cite

show abstract

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One-Pot and Solvent Free Synthesis of 3,4-Dihydropyrimidin-2(1H)-Ones Using Recyclable Resin Purolite CT275DR as a Heterogeneous Catalyst via Three-Component Biginelli-Like Reactions

Cited by 1 publication

References 25 publications

Novel Dihydropyrimidinones: Molecular Docking, Synthesis and Anti-Neoplastic Activity

Novel Dihydropyrimidinones: Molecular Docking, Synthesis and Anti-Neoplastic Activity

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