One Pot Multicomponent Synthesis of Novel Thiazolopyrimidines

Abstract

A novel, solvent-free, simple, eco-friendly and one-pot multicomponent synthesis of various thiazolopyrimidines is studied. Conventional heating the mixture of amine, aldehyde and βketoester or 1,3-diketone under solvent free conditions afforded the thiazolopyrimidines compound in good to excellent yields. Further, a boron trifluoride mediated intermolecular cyclization to provide a novel tetra cyclic system is also reported. 1 H NMR, 13 C NMR, IR and Mass spectroscopy and single crystal analysis were used for identification of these compounds.