One-Pot Sequential Approach for the Construction of Highly Functionalized Triazolo[4,3-<i>c</i>]pyrimidine Library

Vilapara, Kalpesh V.; Butani, Himanshu H.; Gami, Sagar P.; Khunt, Hasmukh R.; Naliapara, Yogesh T.

doi:10.1080/00397911.2015.1083579

Cited by 5 publications

(2 citation statements)

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“…[109] Iodobenzenediacetate was used as a cyclizing agent for the synthesis of a novel [1,2,4]-triazolo[4,3-c]pyrimidine-8carboxamide derivatives 147 (55-81 %) via oxidative cyclization of hydrazono-1,6-dihydropyrimidine-5-carboxamide in dichloromethane as indicated in Scheme 100. [110] An efficient two-step synthesis of 3-benzyl-5-chloro-7methyl-3H-[1,2,3]-triazolo [4,5-d]pyrimidine 148 (70 % in the last step) was developed by Mozafari et al [111] Initially, 2,4dichloro-6-methylpyrimidin-5-amine substituted with benzylamine at C-4 position followed by treatment with sodium (86-96 %) as presented in Scheme 102. [112] Said et al [113]…”

Section: Other Methods For Triazolopyrimidines Synthesismentioning

confidence: 99%

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Different Synthetic Methods for the Preparation of Triazolopyrimidines and their Biological Profile

et al. 2023

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One or more nitrogen‐containing molecules constitute an important class of heterocyclic compounds in organic synthesis, due to their reactivity and their presence in many molecules of natural, human or plant origin. These nitrogenous heterocycles play an essential role in various scientific domains, whether they are chemical, biological or pharmacological. N‐heterocycles are the privileged source of many research topics developed by several groups of researchers. Thus, different methods have been developed to access these heterocyclic compounds with nitrogenous rings, such as triazolopyrimidines. In this review, a bibliographic study summarizing the pharmacological importance of the triazolo[1,5‐a]pyrimidine ring, the different synthesis routes of these derivatives as well as their reactivity was reported.

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Section: Other Methods For Triazolopyrimidines Synthesismentioning

confidence: 99%

“…Iodobenzenediacetate was used as a cyclizing agent for the synthesis of a novel [1,2,4]‐triazolo[4,3‐ c ]pyrimidine‐8‐carboxamide derivatives 147 (55–81 %) via oxidative cyclization of hydrazono‐1,6‐dihydropyrimidine‐5‐carboxamide in dichloromethane as indicated in Scheme 100 [110] …”

Section: Triazolopyrimidine Synthesismentioning

confidence: 99%