One‐Pot Synthesis and Anticancer Activity of Novel Pyrazole Hybrids

Abdel‐Motaal, Marwa; El-Senduny, Fardous F.; Shaaban, Saad

doi:10.1002/slct.202101649

Cited by 2 publications

(3 citation statements)

References 36 publications

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“…Synthesized pyrazole 13 derivative (5-oxo-N 0 -(2-oxoindolin-3-ylidene)-3-phenyl-4,5-dihydro-1H-pyrazole-1-carbothiohydrazide), mechanism was discussed as caused 4 T1 cells to die by preventing wound healing and colony formation, delaying the G0/G1 phase of the cell cycle, activating p27 levels, and most likely inducing apoptosis through DNA intercalation. IC50 value of this synthesized derivative was found to be 25 AE 0.4 μm(Figure 14) [58].…”

Section: Applications Of Pyrazole Scaffoldmentioning

confidence: 94%

Pyrazole Scaffold: Strategies toward the Synthesis and Their Applications

Nandurkar¹,

Danao²,

Rokde³

et al. 2023

Strategies for the Synthesis of Heterocycles and Their Applications

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Pyrazoles have a wide range of applications in medicinal chemistry, drug discovery, agrochemistry, coordination chemistry, and organometallic chemistry. Their popularity has skyrocketed since the early 1990s. Basically, Pyrazole (C3H3N2H) is a simple doubly unsaturated five membered heterocyclic aromatic ring molecule comprising two nitrogen (N) atoms at positions 1- and 2- and three carbon (C) atoms. Pyrazole nucleus is synthesized with various strategies such as multicomponent approach, dipolar cycloadditions, cyclocondensation of hydrazine with carbonyl system, using heterocyclic system and multicomponent approach. A special emphasis is placed on a thorough examination of response processes. Furthermore, the reasons for the increasing popularity of pyrazoles in several fields of science are examined. Pyrazoles have recently been the focus of many techniques, mostly because of how frequently they are used as scaffolds in the synthesis of bioactive chemicals and reactions in various media. The goal of this chapter is to discuss the current developments in synthetic techniques and biological activity related to pyrazole derivatives. The many pharmacological functions of the pyrazole moiety and different synthesis techniques were discussed. This chapter has summarized novel strategies and wide applications of pyrazole scaffold.

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Section: Applications Of Pyrazole Scaffoldmentioning

confidence: 94%

Pyrazole Scaffold: Strategies toward the Synthesis and Their Applications

Nandurkar¹,

Danao²,

Rokde³

et al. 2023

Strategies for the Synthesis of Heterocycles and Their Applications

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“…On the other hand, OSe compounds switch to prooxidants in cells rich with reactive oxygen species (ROS), such as in the case of several cancer cells (e.g., colon, liver, and breast) [ 17 , 18 ]. In this case, OSe compounds use the pre-existing ROS (e.g., H 2 O 2 ) as their substrates and enhance their reaction with different cellular compartments (e.g., endoplasmic reticulum, DNA) and redox-sensible proteins [ 17 , 19 , 20 , 21 , 22 ]. The modification/oxidation of these proteins triggers apoptotic cell death [ 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

“…13 C NMR (101 MHz, DMSO-d 6 ) δ 177 19,. 168.42, 139.41, 132.06, 131.93, 131.63, 130.76, 129.28, 128.36, 128.20, 123.93, 119.59, 30.47, 28.74.…”

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confidence: 99%

Novel Organoselenium Redox Modulators with Potential Anticancer, Antimicrobial, and Antioxidant Activities

2022

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Novel organic selenides were developed in good yields (up to 91%), and their chemical entities were confirmed by IR, MS, and 1H- and 13C-NMR spectroscopy. Their anticancer and antimicrobial properties were estimated against different human cancer (MCF-7 and HepG2) and healthy (WI-38) cell lines, as well as several microbial strains (Escherichia coli, Staphylococcus aureus, and Candida albicans). Furthermore, the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) bioassays were used for the estimation of the antioxidant activities. Generally, cytotoxicity results were more pronounced against the MCF-7 cells than HepG2 cells. Compound 2-((4-((1-hydroxynaphthalen-2-yl)diazenyl)phenyl)selanyl)-N-phenylacetamide (9) was the most cytotoxic, even more than doxorubicin, with IC50 of 3.27 ± 0.2 against 4.17 ± 0.2 µM and twelve-times more selective, respectively. Interestingly, compound 9 exhibited similar antimicrobial potential to reference antibacterial and antifungal drugs and comparable antioxidant activity to vitamin C. These results point to selective cytotoxicity against MCF-7 cells and interesting antimicrobial and antioxidant properties of some newly synthesized organic selenides, which in turn needs further in vitro studies.

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One‐Pot Synthesis and Anticancer Activity of Novel Pyrazole Hybrids

Cited by 2 publications

References 36 publications

Pyrazole Scaffold: Strategies toward the Synthesis and Their Applications

Pyrazole Scaffold: Strategies toward the Synthesis and Their Applications

Novel Organoselenium Redox Modulators with Potential Anticancer, Antimicrobial, and Antioxidant Activities

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