One-pot synthesis, crystallographic characterization, evaluation as in vitro antibacterial and cytotoxic agents of two mercury(II) complexes containing pyridine dicarboxylic acid derivatives

Aliabadi, Alireza; Motieiyan, Elham; Hosseinabadi, Fatemeh; Ghadermazi, Mohammad; Abdolmaleki, Sara

doi:10.1016/j.molstruc.2020.129405

Cited by 18 publications

(6 citation statements)

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“…Then the inhibitory effect of the compounds was evaluated by MTT assay against A375, HT29, and HFF cell lines (Figure S10, Table 2 ). The anti-proliferative effect of ligands was indicated weaker than oxaliplatin on all three cell lines similar to our previous papers 29 . Many studies have proven that inorganic compounds were usually exhibited a more potent cytotoxic effect compared to their organic ligands on cancer cells.…”

Section: Resultssupporting

confidence: 89%

Novel Tl(III) complexes containing pyridine-2,6-dicarboxylate derivatives with selective anticancer activity through inducing mitochondria-mediated apoptosis in A375 cells

Abdolmaleki

Ghadermazi

Aliabadi

2021

Sci Rep

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Three novel Tl(III) complexes (C1), (C2) and (C3) were synthesized using the one-pot reactions of pyridine dicarboxylic acid derivatives, 2-aminobenzimidazole and/or 4-aminopyridine, and also thallium(III) nitrate trihydrate metal salt. The structure of all three complexes was determined by the single-crystal X-ray diffraction. C1 and C2 were realized to be isostructural with disordered square anti-prismatic geometry and for C3 arrangement of the distorted tricapped triangular prism was proposed. Cyclic voltammetry measurements on the complexes exhibited that formal potential values are more positive for C1 (E0ˊ 0.109 V) and C3 (E0ˊ 0.244 V) compared to C2 (E0ˊ –0.051 V), versus Ag/AgCl under argon. Moreover, cytotoxicity of the compounds was evaluated in vitro against two cancer cell lines including a human melanoma (A375), a human colon adenocarcinoma (HT29), and also one normal cell human foreskin fibroblast (HFF). The selective and potent cytotoxicity effect was exhibited by C1 and C3 on cancer cell lines. The apoptosis through a caspase-dependent mitochondrion pathway was confirmed by ROS production, MMP reduction, p53 activation, Bax up-regulation, and Bcl-2 down-regulation, cytochrome c release, procaspase-9, and 3 expression, for A375 cells treated to C1 and C3. According to similar cellular uptake of the complexes in A375 cell line, the generation of ROS was considered as an effective agent to justify the inhibition effect C1 and C3 on mentioned cells. Furthermore, arresting the cell cycle in the G2-M phase and inducing apoptosis were indicated by these two complexes.

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Section: Resultssupporting

confidence: 89%

Novel Tl(III) complexes containing pyridine-2,6-dicarboxylate derivatives with selective anticancer activity through inducing mitochondria-mediated apoptosis in A375 cells

Abdolmaleki

Ghadermazi

Aliabadi

2021

Sci Rep

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“…The values reported in this research work were similar to some work reported in recent years. 5,27,32 Based on DZI values, the biggest diameter for the zone of growth inhibition was exhibited for two compounds toward P. vulgaris and MIC values for them were observed to be close to each other in ATCC 19615 and ATCC 12228 species. The evaluations verified that Gram-positive bacteria were less sensitive to the toxicity of PA-4/ZnO@PMT or PA-4 (DZI of 4-7 mm) than Gram-negative bacteria (DZI of 6-13 mm).…”

Section: Papermentioning

confidence: 95%

“…The values of IC 50 were determined after two days. 32,33 Cell morphology analysis. A431 cells were seeded in 6-well plates for 24 h and then treated with the polymer at halfmaximal inhibitory concentration (IC 50 ) for two days at 37 °C under 5% CO 2 .…”

Section: Cytotoxic Assays Via Mtt Assaysmentioning

confidence: 99%

“…b Glass transition temperature was recorded at a heating rate of performance against cancer cell lines in some cases or relatively close to them. 27,32,33,40 High selectivity toward cancer cell lines is a significant property that merits further studies of this compound in the field of anticancer properties. Such features may arise due to the effectiveness of this compound on disproportionating H 2 O 2 and generating active intermediates.…”

Section: Biological Evaluationmentioning

confidence: 99%

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The preparation of novel poly(ether-amide)s based on spiro[fluorene-9,9′-xanthene] and a polyamide/polymer-coated ZnO nanocomposite: thermal, optical, biological, and methylene blue dye adsorption attributes

2022

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“…All the tests were carried out in triplicate. The values of IC 50 were determined after 2 days 46,47 …”

Section: Methodsmentioning

confidence: 99%

Novel cardo‐type heat‐resistant polyimides bearing 9H‐xanthene and polymer‐based nanocomposite consisting of NH₂‐terminated TiO₂: Synthetic strategies, extraction of methylene blue dye, and biological activities

Khaki

Namazi

Amininasab

2022

Journal of Polymer Science

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In the present study, a series of cardo‐type novel polyimides (PI)s containing xanthene groups was synthesized. All the polymers were amorphous in nature with inherent viscosities in the range of 0.72–0.91 dl/g. Study of thermal behavior showed that PIs have excellent thermal stability with 10% weight loss at temperatures (Td10%) between 426 and 528 °C, glass transition‐related temperatures (Tg) in the range of 292–305 °C, and weight residual at 700 °C ranged from 55% to 68% under N2 atmosphere. Xanthene and fluorene presence, progressed the PIs solubility and also induced good biological activities. The in vitro anticancer activity of the 6FD‐derived PI against the A431 (epidermoid carcinoma) cells showed an IC50 value of 29.3 μM. In the next part of the work, a polymer‐based composite (PI‐B/m‐TiO2@HBP) was prepared by inscribing 20 wt% of hyperbranched polyamide‐grafted TiO2 nanoparticles into BTDA‐derived PI‐B matrix, and compared with the unfilled PI, its photoluminescence intensity and thermal stability properties were increased. The PI‐B and nanocomposite exhibited good antibacterial activity against six bacterial strains. In the following, study of methylene blue (MB) dye adsorption from aqueous solution by the obtained PIs and PI‐B/HBP@TiO2 was carried out and removal efficiency values were found above 80.62%.

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One-pot synthesis, crystallographic characterization, evaluation as in vitro antibacterial and cytotoxic agents of two mercury(II) complexes containing pyridine dicarboxylic acid derivatives

Cited by 18 publications

References 50 publications

Novel Tl(III) complexes containing pyridine-2,6-dicarboxylate derivatives with selective anticancer activity through inducing mitochondria-mediated apoptosis in A375 cells

Novel Tl(III) complexes containing pyridine-2,6-dicarboxylate derivatives with selective anticancer activity through inducing mitochondria-mediated apoptosis in A375 cells

The preparation of novel poly(ether-amide)s based on spiro[fluorene-9,9′-xanthene] and a polyamide/polymer-coated ZnO nanocomposite: thermal, optical, biological, and methylene blue dye adsorption attributes

Novel cardo‐type heat‐resistant polyimides bearing 9H‐xanthene and polymer‐based nanocomposite consisting of NH₂‐terminated TiO₂: Synthetic strategies, extraction of methylene blue dye, and biological activities

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One-pot synthesis, crystallographic characterization, evaluation as in vitro antibacterial and cytotoxic agents of two mercury(II) complexes containing pyridine dicarboxylic acid derivatives

Cited by 18 publications

References 50 publications

Novel Tl(III) complexes containing pyridine-2,6-dicarboxylate derivatives with selective anticancer activity through inducing mitochondria-mediated apoptosis in A375 cells

Novel Tl(III) complexes containing pyridine-2,6-dicarboxylate derivatives with selective anticancer activity through inducing mitochondria-mediated apoptosis in A375 cells

The preparation of novel poly(ether-amide)s based on spiro[fluorene-9,9′-xanthene] and a polyamide/polymer-coated ZnO nanocomposite: thermal, optical, biological, and methylene blue dye adsorption attributes

Novel cardo‐type heat‐resistant polyimides bearing 9H‐xanthene and polymer‐based nanocomposite consisting of NH2‐terminated TiO2: Synthetic strategies, extraction of methylene blue dye, and biological activities

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Novel cardo‐type heat‐resistant polyimides bearing 9H‐xanthene and polymer‐based nanocomposite consisting of NH₂‐terminated TiO₂: Synthetic strategies, extraction of methylene blue dye, and biological activities