One-Pot Three Component Domino Reaction for the Synthesis of Novel Isoxazolo[2,3-<i>c</i>][1,3,5]Thiadiazepin-2-Ones Catalyzed by <i>PTSA</i>—A Green Chemistry Approach

Abstract

The synthesis of novel isoxazolo[2,3-c][1,3,5]thiadiazepin-2-ones has been achieved in excellent yields by one-pot three-component Domino reaction without the production of toxic waste products by using p-toluene sulfonic acid (PTSA) as a Lewis acid catalyst. PTSA plays a crucial role in the success of the reaction, as well as for increasing reaction rate.

Design and synthesis of a new porous organic polymer equipped with N‐propyl sulfamic acid functionalities: As an efficient heterogeneous catalyst for the synthesis of 1,8‐dioxo‐octahydroxanthene derivatives

“…Developing simple, general, clean, and practical synthetic procedures for the efficient production of widely used organic materials from readily available and affordable reagents has been a major challenge in organic and industrial synthesis from years ago. Accordingly, one‐pot multi‐component reactions have attracted considerable attention by producing the target products in a single synthetic operation step without separating intermediates which will lead to reducing energy consumption, reaction time, waste materials, and consequently develop an environmentally friendly process. In addition, from the green chemistry point of view promotion of simple and neat protocols in synthetic chemistry has achieved enormous significance over the past few decades.…”