One Pot Two Step Synthesis of 2-Arylidenehydrazinyl-4-arylthiazole

Abstract

An efficient, simple one pot, two step procedure has been developed for the synthesis of 2-arylidenehydrazinyl-4-arylthiazole. The reaction of aromatic aldehyde, thiosemicarbazide and phenacyl bromide gave the desired products in good yield. The first reaction product thiosemicarbazone was obtained on reaction with aromatic aldehyde and thiosemicarbazide; without isolating this directly treated with phenacyl bromide in presence of acidic buffer at room temperature desired product was obtained with simple workup procedure.

Boronic acid functionalized silica‐coated Fe3O4 as a novel magnetically separable catalyst for the synthesis of hydrazinyl thiazoles

“…The simplest synthetic approach to obtain hydrazinyl thiazole involves a one‐pot reaction of aryl aldehyde, phenacyl halide, and thiosemicarbazide. The catalysts such as CuO NPs/TiO 2, 45 CH 3 COOH, 46 PEG‐400, 47 [PDBMDIm]Br 48 and sulphamic acid 49 have been explored. Catalyst‐free microwave‐assisted method has also been employed for the synthesis of hydrazinyl thiazole 50 .…”