We define and study Toeplitz operators on the Fréchet space of all holomorphic functions on finitely connected domains in the Riemann sphere. We completely characterize Fredholm, semi-Fredholm and invertible operators belonging to this class. As a result, we obtain a characterization of these classes of operators in the unit disk case. As a motivation we formulate and analyze the Riemann–Hilbert problem in the space of all holomorphic functions on the domains which we consider.