One step closer to the elimination of primary graft dysfunction

Charles, Eric J.; Krön, Irving L.

doi:10.1016/j.jtcvs.2014.10.010

Cited by 1 publication

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“…Notably, PH patients with the detected SNP rs6557421 genotype had a 10-fold-higher risk to develop PH in comparison to healthy control samples. Cantu et al searched for genetic variations that might increase the risk of primary graft dysfunction (PGD) after lung transplantation by a SNP set analysis [931,932]. Rejection of the grafted lung and subsequent organ dysfunction is a major cause of death during the early transplantational period, affecting up to 30% of all patients [933][934][935].…”

Section: Role Of Nox3 During Lung Diseasesmentioning

confidence: 99%

NADPH Oxidase 3: Beyond the Inner Ear

Herb

2024

Antioxidants

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Reactive oxygen species (ROS) were formerly known as mere byproducts of metabolism with damaging effects on cellular structures. The discovery and description of NADPH oxidases (Nox) as a whole enzyme family that only produce this harmful group of molecules was surprising. After intensive research, seven Nox isoforms were discovered, described and extensively studied. Among them, the NADPH oxidase 3 is the perhaps most underrated Nox isoform, since it was firstly discovered in the inner ear. This stigma of Nox3 as “being only expressed in the inner ear” was also used by me several times. Therefore, the question arose whether this sentence is still valid or even usable. To this end, this review solely focuses on Nox3 and summarizes its discovery, the structural components, the activating and regulating factors, the expression in cells, tissues and organs, as well as the beneficial and detrimental effects of Nox3-mediated ROS production on body functions. Furthermore, the involvement of Nox3-derived ROS in diseases progression and, accordingly, as a potential target for disease treatment, will be discussed.

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Section: Role Of Nox3 During Lung Diseasesmentioning

confidence: 99%

NADPH Oxidase 3: Beyond the Inner Ear

Herb

2024

Antioxidants

View full text Add to dashboard Cite

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One step closer to the elimination of primary graft dysfunction

Cited by 1 publication

References 1 publication

NADPH Oxidase 3: Beyond the Inner Ear

NADPH Oxidase 3: Beyond the Inner Ear

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