One Step Facile Synthesis of Amine-Functionalized COF-1 with Enhanced Hydrostability

Water-dispersible PEG-curcumin/amine-functionalized covalent organic framework nanocomposites as smart carriers for in vivo drug delivery

“…However, the intrinsic limitations of COF materials, including their poor physiological stability, nonspecific targeting, and low cell-membrane permeability, severely restrain their practical implementation, and research on COFs in drug delivery remains in its infancy. Despite pioneering studies uncovering the great potential of COFs in drug delivery 22 – 25 , further optimization in the following aspects must be considered for the design of optimal drug-delivery carriers for in vivo applications. (1) Optimal size: the optimal particle size for efficient cellular uptake is below 200 nm.…”

“…The integration of polymers and porous materials has been reported in metal-organic frameworks (MOFs)/polymer composites 29 – 31 , which could be pre-prepared 29 , 30 or post-prepared 31 by the formation of MOF crystals using polymeric linkers or the attachment of polymer chains onto the functional ligand of MOF crystals. An amine-functionalized COF-1 has been reported by mixing 3-aminopropyl triethoxysilane (APTES) into established COF-1 recipe via Brønsted-type interactions 25 . In addition, monofunctional curcumin (CCM) derivatives modified by polyethylene glycol (PEG) hold three advantages: (a) the presence of free phenolic groups endows CCM with antioxidant biological activity 32 ; (b) CCM could be used as a fluorescent label for tracking; and (c) using monofunctional derivatives to modify polymers could form soluble conjugates in high yields, while using bifunctional derivatives would result in cross-linked products with poor solubility 33 .…”

Optical glucose sensing using ethanolamine–polyborate complexes

“…23 The appearance of multiple peaks can be correlated to a dynamical equilibrium of various polyborate species upon dispersion in D 2 O. 12 Indeed, several studies in literature [24][25][26][27][28] have shown that 11 In our case, the four peaks are located at À18.8 ppm, À3.0 ppm, 9.8 ppm and 11.0 ppm. Such shift can be expected as different amine groups were utilized in the above-mentioned studies, (i.e.…”

“…10 The hypothesized reason behind such discrepancy is that only the B-COF frameworks containing weakly acidic BÁO(H)ÁC defect sites can be stabilized by forming a Brønsted-type interaction with the N-donors. 11 Boric acid, if compared to the boronic acids employed in COFs, shows specular reactivities with condensation routes forming metaboric acid and fused boroxole rings, as well as boronic ester linkages.…”

“…11 B NMR spectrum deconvolutions (solvent D 2 O) of the complex produced by pyrolysis of boric acid and ethanolamine at a 1 : 5 stoichiometric ratio (B-MEA B/N 1 : 5). The deconvolution was obtained by fitting the curve using four Gaussian distributions (R 2 = 0.9984).…”