One‐step Preparative Separation of Two Polyhydroxystilbenes from <i>Rheum likiangense</i> Sam. by High‐speed Counter‐current Chromatography

Wang, Xiaoyan; Wang, Honglun; Ding, Chenxu; Suo, Yourui

doi:10.1002/pca.2373

Cited by 7 publications

(5 citation statements)

References 16 publications

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“…Hence, simple and convenient methods have gained growing importance in the activity‐guided preparation separation for not only S . doederleinii , but also the other herbal medicines (Frighetto et al ., ; Wang et al ., ; Xian et al ., ).…”

Section: Introductionmentioning

confidence: 97%

“…In addition, the ingredients obtained from the herbal medicine studied are numerous, possibly causing aimlessness and time-consuming screening process for evaluation of their bioactivity. Hence, simple and convenient methods have gained growing importance in the activity-guided preparation separation for not only S. doederleinii, but also the other herbal medicines (Frighetto et al, 2005;Wang et al, 2012;Xian et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Preparative Isolation of six Anti‐Tumour Biflavonoids from Selaginella Doederleinii Hieron by High‐Speed Counter‐Current Chromatography

Zhao

et al. 2013

Phytochemical Analysis

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Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Preparative Isolation of six Anti‐Tumour Biflavonoids from Selaginella Doederleinii Hieron by High‐Speed Counter‐Current Chromatography

Zhao

et al. 2013

Phytochemical Analysis

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“…Modern pharmacology has demonstrated that rhubarb can cure constipation, hyperlipidaemia, hepatic injury and diabetes[ 2 – 5 ]. Chemical analysis shows that rhubarb contains anthraquinones, tannins, polyose, phenylbutazones, and stilbenes [ 6 – 9 ]. Relevant studies show that different active pharmaceutical ingredients (API) have different pharmacological activities, for example, emodin has effects in preventing viral infections, tumor, atherosclerosis, fungal infections and allergies [ 10 – 12 ].…”

Section: Introductionmentioning

confidence: 99%

Influence of the Environmental Factors on the Accumulation of the Bioactive Ingredients in Chinese Rhubarb Products

Ren

et al. 2016

PLoS ONE

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To provide a basis for controlling the quality of rhubarb under artificial cultivation, the present work was designed to evaluate the contents of 14 active pharmaceutical ingredients (API) of rhubarb in major rhubarb production areas in China and analyze the correlations between the contents of API and such factors as species, geographic distribution and soil. The levels of fourteen API in rhubarb were measured using HPLC. The geographic distributions were collected using GPS and the nutrients in the soil were measured using the methods in the literature. The results showed that the levels of major API vary significantly among plants of different locations according to variance analysis. The species factor has few obvious effect on the overall properties of the rhubarb by the cluster analysis because of the two source species occurring in all divided three groups. However, Rheum tanguticum Maxim.ex Balf. is less effective at synthesizing and accumulating 9 API out of 14 than Rheum palmatum L. The correlation analysis and regression analysis also indicated that a lower latitude should be considered in the accumulation of API and a lower longitude should be considered to produce more compound anthraquinones. Lower levels of total P, rapidly available P and available molybdenum (Mo) and higher available K and available Zn in the soil were significantly correlated to accumulation of API in rhubarb. These results provide a basis for the clinical application and controlling the levels of the major API of rhubarb during artificial cultivation.

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“…The literature survey performed revealed over 50 publications that reported a sample loading of one or more grams, ,,,,,− ,,,− ,,,,− as summarized in S4, Supporting Information. Ion-exchange methods have been shown to increase the loading capacity of CCS instruments.…”

Section: Optimization Of Ccs Operation Parametersmentioning

confidence: 99%

Countercurrent Separation of Natural Products: An Update

et al. 2015

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This work assesses the current instrumentation, method development, and applications in countercurrent chromatography (CCC) and centrifugal partition chromatography (CPC), collectively referred to as countercurrent separation (CCS). The article provides a critical review of the CCS literature from 2007 since our last review (J. Nat. Prod.2008, 71, 1489–1508), with a special emphasis on the applications of CCS in natural products research. The current state of CCS is reviewed in regard to three continuing topics (instrumentation, solvent system development, theory) and three new topics (optimization of parameters, workflow, bioactivity applications). The goals of this review are to deliver the necessary background with references for an up-to-date perspective of CCS, to point out its potential for the natural product scientist, and thereby to induce new applications in natural product chemistry, metabolome, and drug discovery research involving organisms from terrestrial and marine sources.

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One‐step Preparative Separation of Two Polyhydroxystilbenes from Rheum likiangense Sam. by High‐speed Counter‐current Chromatography

Abstract: An optimised HSCCC method has been established for large-scale preparative separation of PHS compounds from Rheum likiangense Sam.

Cited by 7 publications

References 16 publications

Preparative Isolation of six Anti‐Tumour Biflavonoids from Selaginella Doederleinii Hieron by High‐Speed Counter‐Current Chromatography

Preparative Isolation of six Anti‐Tumour Biflavonoids from Selaginella Doederleinii Hieron by High‐Speed Counter‐Current Chromatography

Influence of the Environmental Factors on the Accumulation of the Bioactive Ingredients in Chinese Rhubarb Products

Countercurrent Separation of Natural Products: An Update

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