One-step process for the preparation of fast-response soft actuators based on electrospun hybrid hydrogel nanofibers obtained by reactive electrospinning with in situ synthesis of conjugated polymers

Miranda, Diego Oliveira; Dorneles, Matheus Figueiredo; Oréfice, Rodrigo Lambert

doi:10.1016/j.polymer.2020.122590

Cited by 24 publications

(14 citation statements)

References 27 publications

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“…On the other hand, Chee and co-workers claimed a 400–600% swelling ratio for the PVA/polyacrylic acid (PAA) bilayer NF . In another study, Miranda et al used the PVA/polyaniline (PANI) blend to produce hydrogel NF and reported a swelling ratio of ∼600% . As observed, the swelling ratios that we found in our study are correlated with the previous ones in which highly hydrophilic polymer types were used to generate electrospun hydrogel-featured NFs and this suggested the hydrogel-forming capability of our samples. − For degradation tests in PBS buffer (pH 7.4), each sample independent of their compositions degraded ≥87% ( p < 0.05: significantly different) (Figure c).…”

Section: Results and Discussionsupporting

confidence: 89%

“…In another study, Miranda et al used the PVA/polyaniline (PANI) blend to produce hydrogel NF and reported a swelling ratio of ∼600% . As observed, the swelling ratios that we found in our study are correlated with the previous ones in which highly hydrophilic polymer types were used to generate electrospun hydrogel-featured NFs and this suggested the hydrogel-forming capability of our samples. − For degradation tests in PBS buffer (pH 7.4), each sample independent of their compositions degraded ≥87% ( p < 0.05: significantly different) (Figure c). The percentages for the thermally treated samples implied that the high concentration of HPγCD within the NF (∼88 to 91%, w/w) had the most influence on degradation of the samples due to a significantly high aqueous solubility of HPγCD (≥500 mg/mL) .…”

Section: Results and Discussionsupporting

confidence: 86%

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Green Electrospinning of Chitosan/Pectin Nanofibrous Films by the Incorporation of Cyclodextrin/Curcumin Inclusion Complexes: pH-Responsive Release and Hydrogel Features

Çelebioğlu

Saporito

Uyar

2022

ACS Sustainable Chem. Eng.

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Chitosan and pectin are abundantly found biopolymers in nature that are derived from renewable resources. On the other hand, the chemical structure of these biopolymers creates problems during the production of their nanofibrous films by the electrospinning technique. In this study, the electrospinning of the chitosan/pectin blend system was facilitated using natural, starch-derived cyclodextrin (hydroxypropyl-γ-cyclodextrin (HPγCD)) molecules and nanofibrous films were generated with a green approach in which there was no use of a carrier polymer or toxic solvent. The nanofibrous films obtained with different chitosan/pectin ratios showed high swelling (water uptake) property (∼1340 to 1510%), which suggested the hydrogel-forming capacity of these electrospun films. Here, the HPγCD molecules were further utilized and curcumin, a well-known bioactive compound, was encapsulated into HPγCD cavities by inclusion complexation. This time, HPγCD–curcumin inclusion complexes (ICs) were mixed with chitosan/pectin blends using the predetermined ratios, and freestanding nanofibrous films were successfully produced having an ∼89% curcumin loading efficiency. The ultimate nanofibrous films demonstrated a pH-responsive release profile of curcumin in pH 5.4 and 7.4 media besides their high swelling feature. Briefly, chitosan/pectin/CD-IC nanofibrous films can be a promising alternative to biomaterials produced with synthetic sources by holding the unique properties of biopolymers, CD, and nanofibers.

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Section: Results and Discussionsupporting

confidence: 89%

Section: Results and Discussionsupporting

confidence: 86%

Green Electrospinning of Chitosan/Pectin Nanofibrous Films by the Incorporation of Cyclodextrin/Curcumin Inclusion Complexes: pH-Responsive Release and Hydrogel Features

Çelebioğlu

Saporito

Uyar

2022

ACS Sustainable Chem. Eng.

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“…Both the core and shell solutions were extruded at the same rate of 1.5 mL h −1 . The configuration of the UV source applied in this work consisted of three 8 W UVA lamps and an 8 W UVB lamp that directed the light to the space between the needle and the collector 12 . At the same time, half of the rotating collector passed periodically inside a chamber containing UV lamps that guaranteed the polymerization and stabilization of the fibers.…”

Section: Methodsmentioning

confidence: 99%

“…Elimination of the solvent leads to the formation of highly stretched usually submicron fibers that can be collected to yield unoriented or oriented non‐woven mats. Fibers produced in this way have been tested in many applications including tissue engineering, 9 drug delivery systems, 10 sensors, 11 actuators 12 etc. Electrospinning is also famous for its high versatility that enables the preparation of products with different architectures, e.g.…”

Section: Introductionmentioning

confidence: 99%

Core–shell electrospun fiber architecture used as a nanoreactor to synthesize conjugated polymers

Miranda

Dorneles

Oréfice

2022

Polymer International

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Chemical reactions in a confined nanometer-sized space can have a dramatic impact on conversion, reaction rate and macromolecular texture. In this work, the idea of synthesizing conjugated polymers (polyaniline, PANI) within the core of a core-shell submicron electrospun fiber was tested. To this end, acrylamide/acrylic acid solution containing ammonium persulfate was photopolymerized during electrospinning to prepare the shell of a core-shell electrospun fiber, while the core was produced based on an aniline-rich solution. Polymerization of aniline occurred during the electrospinning through the contact of ammonium persulfate and aniline at the core of the newly formed fibers as observed by AFM electrical current mode and by Fourier transform infrared results that showed the presence of a highly doped and conductive emeraldine PANI. The ability of the shell of the fibers to swell in water and to lead to materials with low elastic modulus, as common hydrogels, was also detected through AFM images and indentation curves in water.

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“…Many works have been devoted to the study of fibrous hydrogels as soft actuators. Miranda et al [34] reported a hybrid nanofiber hydrogel based on poly (acrylamide and acrylic acid) mixed with aniline; the electroactive response was assessed in an electrochemical cell. The hybrid material exhibited a high electrical conductivity, reaching values near 0.01 S cm −1 , as well as a fast time response (2.5 mm s −1 ) and reversible displacement at low electrical potential (1 V) in 1 MΩ cm distilled water.…”

Section: Introductionmentioning

confidence: 99%

Chitosan/PVA Nanofibers as Potential Material for the Development of Soft Actuators

2023

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Chitosan/PVA nanofibrous electroresponsive soft actuators were successfully obtained using an electrospinning process, which showed fast speed displacement under an acidic environment. Chitosan/PVA nanofibers were prepared and characterized, and their electroactive response was tested. Chitosan/PVA nanofibers were electrospun from a chitosan/PVA solution at different chitosan contents (2.5, 3, 3.5, and 4 wt.%). Nanofibers samples were characterized using Fourier transform infrared analyses, thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), optical microscopy, and tensile test. The electroactive behavior of the nanofiber hydrogels was tested under different HCl pH (2–6) under a constant voltage (10 V). The electroactive response test showed a dependence between the nanofiber’s chitosan content and pH with the bending speed displacement, reaching a maximum speed displacement of 1.86 mm−1 in a pH 3 sample with a chitosan content of 4 wt.%. The results of the electroactive response were further supported by the determination of the proportion of free amine groups, though deconvoluting the FTIR spectra in the range of 3000–3700 cm−1. Deconvolution results showed that the proportion of free amine increased as the chitosan content was higher, being 3.6% and 4.59% for nanofibers with chitosan content of 2.5 and 4 wt.%, respectively.

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One-step process for the preparation of fast-response soft actuators based on electrospun hybrid hydrogel nanofibers obtained by reactive electrospinning with in situ synthesis of conjugated polymers

Cited by 24 publications

References 27 publications

Green Electrospinning of Chitosan/Pectin Nanofibrous Films by the Incorporation of Cyclodextrin/Curcumin Inclusion Complexes: pH-Responsive Release and Hydrogel Features

Green Electrospinning of Chitosan/Pectin Nanofibrous Films by the Incorporation of Cyclodextrin/Curcumin Inclusion Complexes: pH-Responsive Release and Hydrogel Features

Core–shell electrospun fiber architecture used as a nanoreactor to synthesize conjugated polymers

Chitosan/PVA Nanofibers as Potential Material for the Development of Soft Actuators

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