“…Fifteen studies evaluated marginal adaptation after 12 months, with one study [ 17 ] presenting three experimental groups, and another [ 40 ] two experimental groups, totaling 18 experimental groups ( Fig 4 ). Among the 18 groups, 12 presented results that favored the control group (conventional composite), [ 19 , 25 , 27 , 28 , 30 , 33 , 34 , 37 , 40 , 41 ] two that favored the experimental group (resins with modified monomers) [ 32 , 35 ], one that did not favor any of the groups, since results were similar for both groups [ 29 ], two presented no marginal adaptation alterations in both groups [ 17 , 26 ], and one study reported that all restorations in both groups demonstrated some sort of marginal adaptation alteration [ 38 ]. Meta-analysis demonstrated that at the 12-month follow-up assessment, the overall effect of methacrylates-based composite resins was significantly better than the ormocer, silorane and bulk-fill composites (p = 0.001).…”