One year in autoimmunity

Selmi, Carlo

doi:10.1016/j.autrev.2007.09.001

Cited by 8 publications

(3 citation statements)

References 130 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Once again, this is in agreement with the clinical evidence which, supported by longitudinal 28,29 studies, denies a prognostic role for AMA or an association with response to UDCA despite its anti‐apoptotic effects 30 . PBC is considered a model autoimmune disease; we have not discussed herein the mechanisms of autoimmunity but instead refer to recent reviews that focus on this issue 31–40 . Specific discussion on the relationship of the pathophysiology of autoimmunity and PBC has recently been published 41 …”

Section: Discussionsupporting

confidence: 78%

Ursodeoxycholic acid reduces CpG‐induced IgM production in patients with primary biliary cirrhosis

Kikuchi

Hsu

Hosoya

et al. 2009

Hepatology Research

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 78%

Ursodeoxycholic acid reduces CpG‐induced IgM production in patients with primary biliary cirrhosis

Kikuchi

Hsu

Hosoya

et al. 2009

Hepatology Research

Self Cite

View full text Add to dashboard Cite

show abstract

“…The information provided using this proteomic approach has indicated new deregulated autoantigen/autoantibody expression patterns, not only in classical autoimmune diseases such as lupus, Behçet 's and arthritis [120] that are characterized by disorders of immune responses and autoimmune impairment, but also in cancer [121][122][123] and some chronic diseases like allergic rhinitis, chronic hepatitis, idiopathic cardiomyopathy, male infertility and cystic fibrosis [124,125].…”

Section: Immunoproteomicsmentioning

confidence: 99%

Two‐dimensional gel electrophoresis and mass spectrometry for biomarker discovery

Penque

2009

Proteomics Clinical Apps

View full text Add to dashboard Cite

The proteome project, initiated in 1995, was made possible by 2-DE combined with MS. The project main objective was and remains the identification of all proteins expressed by a cell, tissue or organism in a given time and condition. Following this objective, the global profiling of proteins in health versus pathological state by the 2-DE/MS-based proteomic approach has contributed to the elucidation of the basic mechanisms of disease by discovering candidate disease biomarkers and disease targets for new drug development. This review will briefly summarize the historical evolution of 2-DE up to today, and review 2-DE/MS technology and its specific methods of study of immunoresponse (immunoproteomics), PTM of proteins, complex proteinprotein interactions (interactome), the proteome of cell membrane and intracellular proteome turnover in disease biomarker discovery. 2-DE historical evolutionGlobal profiling of proteins in healthy versus pathological states is a strategy to discover biomarkers for early diagnostics, disease progression, treatment response and novel targets for therapeutic drugs development. The idea of making an inventory of all the proteins in a cell, tissue or organism with normal or abnormal physiology, was (re)initiated in the middle of the 1990s with the proteome project [1]. Since then, many technologies to make the analysis of the proteome a reality have been united.The perfect technological 'marriage' that made the proteome project feasible was between high resolution 2-DE for separation of large numbers of proteins and MS for identification and characterization of the proteins displayed on this gel [2]. However, before this happy union occured, science and technology devoted to protein study had a long journey until 2-DE and MS combination was possible (Fig. 1). It started in the last century, in 1937, when Tiselius [3] introduced electrophoresis technique as a modification of Reiner's early concept (1927) [4] to analyse a complex mixture of proteins such as serum proteins. Only 20 years later, in 1959, electrophoresis on a gel support formed by crosslinked polymerization of Cyanogum 41, a commercial name for two organic monomers, acrylamide and the crosslinking agent, N,N1-methylenebisacrylamide, was shown to be useful and was named PAGE by Raymond and Weintraub [5]. The adaptation of polyacrylamide gel to IEF in a stable pH gradient, developed by Svensson in 1962 [6], was possible by the end of the 1960s [7][8][9]. About this time, the 2-D by combining IEF to separate undenatured proteins according to their charge and gradient SDS-PAGE for a second separation, according to their molecular mass, was for the first time introduced by Kenrick and Margolis (1970) [10]. Only in 1975, was IEF in denaturing conditions, as known today, used to follow the 2-D PAGE and it was described in three independent works [11][12][13]. The most powerful demonstraCorrespondence: Dr. Deborah Penque, Laboratório de Proteó-mica, Departamento de Genética, Instituto Nacional de Saúde, Dr. Ricardo Jorge, I.P., A...

show abstract

“…As doenças auto-imunes (DAI) constituem um grupo complexo e heterogêneo de doenças que atingem cerca de 5 a 8% da população mundial (BAECHLER et al, 2006). Estas doenças são caracterizadas por anormalidades nos processos de regulação da tolerância imunológica a antígenos próprios e resultam da destruição tecidual por linfócitos T autoreativos e auto-anticorpos (DAVIDSON e DIAMOND, 2001;MARRACK et al, 2001;SELMI, 2007;MACKAY et al, 2008 BURT et al, 2002;BONNOTTE, 2004;GOODNOW et al, 2005;SAKAGUCHI, 2005).…”

Section: Doenças Auto-imunesunclassified

Avaliação da expressão de genes e proteínas anti- e pró-apoptóticos em pacientes com diabetes mellitus tipo 1 e esclerose múltipla submetidos ao transplante autólogo de células-tronco hematopoéticas

Oliveira¹

View full text Add to dashboard Cite

Na Idade Média, as pessoas acreditavam que a Terra era plana, porque elas tinham ao menos a evidência de seus sentidos; nós acreditamos que ela é redonda não porque um por cento de nós pôde dar as razões científicas para uma crença tão fantástica, mas porque a ciência moderna nos convenceu de que nada que é óbvio é verdadeiro, e que tudo que é mágico, improvável, extraordinário, gigantesco, microscópico, cruel ou excessivo é científico."

show abstract

One year in autoimmunity

Cited by 8 publications

References 130 publications

Ursodeoxycholic acid reduces CpG‐induced IgM production in patients with primary biliary cirrhosis

Ursodeoxycholic acid reduces CpG‐induced IgM production in patients with primary biliary cirrhosis

Two‐dimensional gel electrophoresis and mass spectrometry for biomarker discovery

Avaliação da expressão de genes e proteínas anti- e pró-apoptóticos em pacientes com diabetes mellitus tipo 1 e esclerose múltipla submetidos ao transplante autólogo de células-tronco hematopoéticas

Contact Info

Product

Resources

About