2024
DOI: 10.1101/2024.05.31.596831
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OneSC: A computational platform for recapitulating cell state transitions

Da Peng,
Patrick Cahan

Abstract: Computational modelling of cell state transitions has been a great interest of many in the field of developmental biology, cancer biology and cell fate engineering because it enables performing perturbation experiments in silico more rapidly and cheaply than could be achieved in a wet lab. Recent advancements in single-cell RNA sequencing (scRNA-seq) allow the capture of high- resolution snapshots of cell states as they transition along temporal trajectories. Using these high-throughput datasets, we can train … Show more

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