Onion peel extract increases hepatic low-density lipoprotein receptor and ATP-binding cassette transporter A1 messenger RNA expressions in Sprague-Dawley rats fed a high-fat diet

Antioxidant activity of phenolic extracts from different cultivars of Italian onion (Allium cepa) and relative human immune cell proliferative induction

“…Recent literature is rich in both in vivo and in vitro studies reporting the antithrombotic (Lee et al, 2013), hypolipidemic (Lee et al, 2012b;Srinivasan, 2013), antidiabetic (Jung et al, 2011), antiobesity (Yoshinari et al, 2012), antioxidant (Alpsoy et al, 2013;Lee et al, 2012a), anti-inflammatory (Dorsch et al, 1990), cancer chemopreventive (Wang et al, 2012), and antiparasitic (Aboelhadid et al, 2013;Klimpel et al, 2011) properties of onion bulb extracts. Moreover, accumulated epidemiological studies suggest that a diet rich in onions may also have favorable effects on the risk of acute myocardial infarction (Galeone et al, 2009), and benign prostatic hyperplasia (Galeone et al, 2007).…”

Onion peel tea ameliorates obesity and affects blood parameters in a mouse model of high-fat-diet-induced obesity

“…One possible mechanism by which OPT exerts anti-obesity effects may be via the action of quercetin. In the previous studies, the experimental animals were fed more quercetin than was taken in by the animals in the present study (9,12). The results of the present study suggest that there may be another mechanism underlying the action of OPT.…”

“…It has also been demonstrated that OPE is able to lower blood low-density lipoprotein cholesterol and increase high-density lipoprotein cholesterol levels by increasing the expression of low-density lipoprotein receptor mRNA and mRNA encoding ATP-binding cassette transporter A1 genes (12). Moreover, a review by Sudathip et al (4) reported that green tea extract decreased blood Glu, TG and T-cho levels in diet-induced models of obesity (4).…”

Hypocholesterolemic effect of quercetin-rich onion peel extract in C57BL/6J mice fed with high cholesterol diet

“…Apart from the cholesterol-lowering effect, the extract has proven to be beneficial in averting lipogenesis in the liver (35). Our findings suggest that OP may act as a phytochemical to regulate hypocholesterolemia; however, relevant studies in humans are required to explore its use as a hypocholesterolemic food supplement.…”