Online coupling of matrix solid-phase dispersion to direct analysis in real time mass spectrometry for high-throughput analysis of regulated chemicals in consumer products

Meng, Xianshuang; Sun, Su-Qin; Bai, Hua; Ma, Qiang

doi:10.1016/j.aca.2022.340677

Cited by 8 publications

(1 citation statement)

References 82 publications

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“…Trends in sample preparation for cosmetics analysis have been reviewed previously [19,20]. Extraction procedures such as traditional liquid-liquid extraction (LLE) and solid-liquid extraction (SLE), as well as advanced techniques such as ultrasound-assisted extraction (UAE) [21], supercritical fluid extraction (SFE) [13], solid-phase extraction (SPE) [21], or matrix solid-phase dispersion (MSPD) [22,23], were used for the extraction of coumarins from different types of cosmetics. However, trends are focused toward the environmental friendliness of procedures and the minimization of solvent volumes, sample amounts, and time consumption without decreasing method performance.…”

Section: Introductionmentioning

confidence: 99%

The Application of Pipette-Tip and Magnetic Dummy-Template Molecularly Imprinted Solid-Phase Extraction Coupled with High-Performance Liquid Chromatography with Diode Array and Spectrofluorimetric Detection for the Determination of Coumarins in Cosmetic Samples

Špačková,

Hroboňová,

Jablonský

2024

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In this study, adsorbents based on molecularly imprinted polymers (MIPs) in two solid-phase extraction application forms, pipette tip and magnetic extraction, were used for the selective extraction of coumarins. The pipette-tip solid-phase extraction reduced solvent volumes; the magnetic MIP extraction was simple and effective for phase separation. Parameters affecting extraction, such as the amount of adsorbent, type of washing solvent, volume of the elution solvent, and extraction times for magnetic extraction, were optimized. The MIP-based adsorbents displayed high selectivity and extraction efficiency, resulting in recoveries ranging from 70.3 to 102.0% (RSD % less than 5.5%) for five coumarins under study, 6,7-dihydroxycoumarin-6-β-D-glucoside, coumarin, 7-methoxycoumarin, 6-methylcoumarin, and dicoumarol. The extracts were analyzed by high-performance liquid chromatography with diode array (DAD) and fluorescence (FLD) detectors, reaching limits of quantification of 0.5 and 0.9 µg·mL−1 for coumarin and dicoumarol detected by DAD and 0.001–0.012 µg·mL−1 for the other prohibited simple coumarins when used as a fragrance (detected by FLD). The proposed method was validated and its applicability was shown for the analysis of cosmetic samples like shower gel and perfume.

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