“…The Focused Beam Reflectance Measurement (FBRM) is a well-established method which has found extensive usage in online and in situ particle characterisation within the pharmaceutical and fine chemicals (Kougoulos et al, 2005;Nagy et al, 2008;Saleemi et al, 2012), food (Haddad Amamou et al, 2010;Arellano et al, 2012;Ndoye et al, 2013;Ndoye and Alvarez, 2015) and biotechnology industries (McDonald et al, 2001;Pearson et al, 2003;Jeffers et al, 2003;Whelan et al, 2012). This technique operates on the principle of laser backscattering wherein a laser beam scans in a circular path at a fixed speed through a probe immersed in the solution under study.…”