Online post-column solvent assisted and direct solvent-assisted electrospray ionization for chiral analysis of propranolol enantiomers in plasma samples

Elmongy, Hatem; Ahmed, Hytham M.; Wahbi, Abdel‐Aziz M.; Koyi, Hirsh; Abdel‐Rehim, Mohamed

doi:10.1016/j.chroma.2015.09.051

Cited by 8 publications

(16 citation statements)

References 21 publications

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“…These phenomena can be interpreted as follows: when HCOOH was increased, sufficient ionized H + species were generated to react with LiCoO 2 powder in the solid/liquid interphase, and when the interfacial H + concentration was reduced, the additional ionized H + species could diffuse outward. [23][24][25] Fig. 2 shows that the theoretical LiCoO 2 /HCOOH reactive ratio was 1 : 3.…”

Section: Leaching Of Licoo 2 With Hcoohmentioning

confidence: 94%

Lithium fluoride recovery from cathode material of spent lithium-ion battery

Zheng

Song

et al. 2018

RSC Adv.

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Section: Leaching Of Licoo 2 With Hcoohmentioning

confidence: 94%

Lithium fluoride recovery from cathode material of spent lithium-ion battery

Zheng

Song

et al. 2018

RSC Adv.

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“…The optimal composition resulted in a 30‐fold increase in signal on average. Elmongy et al showed that by post‐column addition of 0.5% formic acid in isopropanol to a normal‐phase chromatography flow the signal‐to‐noise ratio was improved by more than 40‐fold. Carabias‐Martinez et al reported up to 200 times increase in signal‐to‐noise ratio with post‐column base addition in negative ionization mode.…”

Section: Introductionmentioning

confidence: 99%

“…The optimal composition resulted in a 30-fold increase in signal on average. Elmongy et al 14 showed that by post-column addition of 0.5% formic acid in isopropanol to a normal-phase chromatography flow the signal-to-noise ratio was improved by more than 40-fold. Merck (Darmstadt, Germany).…”

Section: Introductionmentioning

confidence: 99%

Optimization of flow splitting and make‐up flow conditions in liquid chromatography/electrospray ionization mass spectrometry

Liigand

Vries

Cuyckens

2019

Rapid Comm Mass Spectrometry

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Rationale In liquid chromatography/mass spectrometry (LC/MS) the LC flow is often split prior to the mass spectrometer, for instance, when collecting fractions of the separated sample for other purposes or when less sensitive parallel detection is applied. The aim of this study is to optimize the actual split ratio and make‐up flow composition. Methods Different types of splitters were evaluated in combination with a make‐up flow. A home‐made 1/10 T‐piece splitter and commercial 1/10, 1/100 and 1/250 splitters were evaluated by continuous and accurate measurements of the actual split ratio throughout the LC gradient. The make‐up flow composition was optimized for maximum electrospray ionization (ESI)‐MS sensitivity in the positive mode using ESI efficiency measurements. Results Altogether 22 different solvent conditions were tested on 20 pharmaceutical compounds with a wide variety of functional groups and physicochemical properties (molecular weight, logP, and pKa). Methanol/10 mM formic acid in water (90/10) provided on average the best results. Conclusions Methanol/10 mM formic acid in water (90/10) proved to be the best make‐up flow composition in relation to the average sensitivity obtained. Stronger acidic conditions using oxalic acid or higher formic acid concentrations had a clear positive effect on the sensitivity of compounds with low ionization efficiency. The tested split ratios were relatively stable over the main part of the gradient but showed some variation at very low and very high organic conditions. Differences were larger with methanol compared with acetonitrile containing solvent compositions and when applied without a column or with very long connecting tubing.

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“…SAESI‐MS allows timesaving, no heating and less solvent consumption. Several applications of various nonpolar or low‐polarity solvent systems have been demonstrated by SAESI‐MS …”

Section: Introductionmentioning

confidence: 99%

“…When the sample is a liquid, continuous injection, continuous monitoring and continuous analysis are often necessary, and an analytical strategy based on the atmospheric pressure chemical ionization (APCI) and electrospray ionization (ESI) mass spectrometry mechanism is appropriate. However, nonpolar or low-polarity solvents extracts, such as petroleum ether extracts, are difficult to analyze applications of various nonpolar or low-polarity solvent systems have been demonstrated by SAESI-MS. 22,[24][25][26] In the study reported here we attempted to perform the direct…”

Section: Introductionmentioning

confidence: 99%

Rapid characterization of nonpolar or low‐polarity solvent extracts from herbal medicines by solvent‐assisted electrospray ionization mass spectrometry

Zhang

Liu

et al. 2018

Rapid Comm Mass Spectrometry

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As a convenient and efficient method, SAESI-MS can be used to directly detect compounds (especially the low-polarity compounds) in nonpolar or low-polarity solvent extracts of herbal medicines, providing abundant chemical information for pharmacological studies. SAESI-MS allows the simultaneous qualitative analysis of multiple compounds in the same complex samples and is thus particularly suitable for the preliminary screening of compounds in complex samples. SAESI-MS can be used to differentiate the different parts of herbal medicines.

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Online post-column solvent assisted and direct solvent-assisted electrospray ionization for chiral analysis of propranolol enantiomers in plasma samples

Cited by 8 publications

References 21 publications

Lithium fluoride recovery from cathode material of spent lithium-ion battery

Lithium fluoride recovery from cathode material of spent lithium-ion battery

Optimization of flow splitting and make‐up flow conditions in liquid chromatography/electrospray ionization mass spectrometry

Rapid characterization of nonpolar or low‐polarity solvent extracts from herbal medicines by solvent‐assisted electrospray ionization mass spectrometry

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