2024
DOI: 10.21203/rs.3.rs-4972022/v1
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Ononin, a natural isoflavone glycoside, alleviates postoperative cognitive dysfunction in aged mice by regulating neuroinflammation and oxidative stress

Ming Li,
Qingmei Peng,
Changlin Chen
et al.

Abstract: Postoperative cognitive dysfunction (POCD) is a common and serious neurological complication. Currently, there is no effective clinical prevention and treatment for POCD. Ononin has been confirmed to exhibit potent neuroprotective effects in many diseases. This study aimed to investigate whether ononin could exert a neuroprotective role against POCD. The animal model of POCD was established in 18-month-old aged mice with unilateral nephrectomy. Ononin (30 mg/kg) was administered intraperitoneally to aged mice … Show more

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