Onyx in an experimental aneurysm model: histological and angiographic results

Abstract

This is the first study reporting the formation of a neointima over the neck of aneurysms embolized with Onyx in a rabbit model. Although the technique is challenging and migration of the liquid embolic agent cannot always be prevented, Onyx has a great potential to achieve a durable occlusion of aneurysms.

In Vivo Experimental Aneurysm Embolization in a Swine Model with a Liquid-to-Solid Gelling Polymer System: Initial Biocompatibility and Delivery Strategy Analysis

“…This process is repeated until a sufficient amount of EVOH is delivered to occlude the aneurysm. Although this technique does promote safe delivery of the copolymer, it results in a technically challenging procedure and prolonged procedure times, with an average of about 95 minutes, as reported in the Cerebral Aneurysm Multicenter European Onyx (CAMEO) trial (29,48).…”

“…When delivered too quickly, DMSO has been shown to induce vessel necrosis and cause vasospasm (11,33,35). As a result of co-formulation with DMSO, EVOH liquid must be delivered very slowly and in stages, making for a challenging delivery technique (29,48).…”

Flat-detector computed tomography in the assessment of intracranial stents: comparison with multi detector CT and conventional angiography in a new animal model

“…The microcatheter and the introducer sheath were removed and the femoral artery was ligated. To avoid superposition of venous structures during intravenous contrast medium injection using an ear vein [18], we punctured the femoral vein using a standard i.v. cannula (Vasofix Safety®, 20 G, B. Braun Melsungen AG, Melsungen, Germany).…”

Main Models of Experimental Saccular Aneurysm in Animals

“…Thus, the authors concluded that from a histological perspective, the elastase-induced aneurysms were the ones most similar to human aneurysms, in addition to exhibiting little spontaneous fibromuscular response compared to the surgical model with venous pouch grafting [71]. Accordingly, the elastase-induced model is currently used in tests for endovascular devices [39][40][41][42].…”