Oocyte quality and embryo quality of infertile women with polycystic ovarian syndrome

Chen, S.; Song, Jie

doi:10.1016/j.fertnstert.2008.07.197

Cited by 3 publications

(3 citation statements)

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“…In contrast, lower fertilization and implantation rates (Chen et al . 2008)[5758] and a lower proportion of meiotically competent oocytes (Chen et al . )[5859] have been reported in PCOS patients.…”

Section: Discussionmentioning

confidence: 99%

Establishing an Anti-Müllerian hormone cutoff for diagnosis of polycystic ovarian syndrome in women of reproductive age-bearing Indian ethnicity using the automated Anti-Müllerian hormone assay

Mahajan

Kaur

2019

J Hum Reprod Sci

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Context: Polycystic ovary syndrome diagnosed by Rotterdam criteria, is the most common cause of anovulatory infertility. The criteria of polycystic ovarian morphology (PCOM) are subject to operator variability and technological advances. Serum anti-Müllerian hormone (AMH) level has been proposed as a more reliable alternative to antral follicle count. There is a paucity of data on use of AMH for diagnosis of PCOS in Indian women. Aim and Objectives: The aim of this study is to determine a cutoff level for AMH that could facilitate diagnosis of PCOS and its phenotypes in women of Indian origin using the automated (Roche) assay and to compare the competence of oocytes in PCOS and non-PCOS women undergoing in vitro fertilization-intracytoplasmic sperm injection (IVF-ICSI). Materials and Methodology: A total of 367 women undergoing treatment at our fertility center between February 2017 and August 2017 were prospectively enrolled in this study. Of these, 133 were diagnosed with PCOS, 69 had isolated PCOM, and 165 (controls) had normal ovaries on ultrasound examination. Serum AMH levels were assessed using the fully automated Roche Elecsys ® immunoassay. Gonadotropin-releasing hormone antagonist protocol was used for IVF-ICSI in all patients. Statistical Analysis Used: Quantitative variables were compared using the Mann–Whitney test. Qualitative variables were correlated using the Chi-square test. P < 0.05 was considered to be statistically significant. Results: Mean AMH concentrations in women with PCOS was higher (7.56 ± 4.36 ng/mL) in comparison to PCOM and controls. Serum AMH concentration >5.03 ng/mL could facilitate diagnosis of PCOS (area under the curve = 0.826); sensitivity –70.68%, specificity of 79.91%. There was no difference in the ratio of mature to total oocytes retrieved in the three groups ( P > 0.05). Mean number of mature oocytes was lower in controls than PCOS and PCOM ( P < 0.001). Conclusions: Serum AMH concentration >5.03 ng/mL could be used as cutoff value for the diagnosis of PCOS in women of Indian origin.

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Section: Discussionmentioning

confidence: 99%

Establishing an Anti-Müllerian hormone cutoff for diagnosis of polycystic ovarian syndrome in women of reproductive age-bearing Indian ethnicity using the automated Anti-Müllerian hormone assay

Mahajan

Kaur

2019

J Hum Reprod Sci

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“…The phosphorylated insulin receptor then phosphorylates the insulin receptor substrate (IRS) proteins situated within the cell membrane. Phosphorylated IRS serves as a binding site for phosphoinositide 3-kinase (PI3K), which then catalyzes the transformation of phosphatidyl-inositol-4,5-bisphosphate (PIP2) into phosphatidylinositol (3,4,5)-trisphosphate (PIP3). Alternatively, PIP2 can be cleaved by phospholipase C (PLC) to generate inositol-1,4,5-trisphosphate (IP3).…”

Section: Role Of Inositol In Insulin Signalingmentioning

confidence: 99%

“…This condition contributes to about 75% of cases involving anovulatory infertility [2,3]. Individuals with PCOS undergoing in vitro fertil-Systematic review of the roles of inositol and vitamin D in improving fertility among patients with polycystic ovary syndrome ization typically yield a higher number of retrieved oocytes than infertile women without PCOS; however, these oocytes, along with the resulting embryos, are of lower quality and maturity [4]. PCOS is diagnosed based on the presence of androgen excess, ovulatory dysfunction, and/or polycystic ovaries.…”

Section: Introductionmentioning

confidence: 99%

Systematic Review of the roles of Inositol and Vitamin D in improving fertility among patients with Polycystic Ovary Syndrome

Katyal,

Kaur,

Ashraf

et al. 2024

Clin Exp Reprod Med

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Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder among reproductive-age women. As a leading cause of anovulatory infertility, it complicates fertility treatments, including in vitro fertilization. The widely accepted 2003 Rotterdam diagnostic criteria for PCOS include sub-phenotypes based on variations in androgen excess, ovulatory dysfunction, and polycystic ovarian morphology. In this systematic review, we examined the impacts of inositol and vitamin D on fertility in PCOS. Adhering to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines, we used relevant keywords to comprehensively search databases including PubMed, Google Scholar, and MDPI. From an initial pool of 345 articles, 10 met the inclusion criteria. The articles suggest that vitamin D and inositol, particularly myo-inositol and D-chiro-inositol, may represent therapeutic options for PCOS. Vitamin D influences ovarian follicular development, glucose regulation, and insulin sensitivity. When combined with metformin therapy, it is associated with improved menstrual regularity and ovulation. Inositol is crucial for cellular signaling, energy metabolism, glucose regulation, and fertility. This systematic review underscores the importance of investigating inositol and vitamin D within a PCOS management strategy, given the disorder’s prevalence and impacts on fertility and metabolic health. Although these agents show promise, additional research could clarify their mechanisms of action and therapeutic benefits. This review emphasizes the need for exploration of effective treatments to improve the quality of life among individuals with PCOS. Inositol and vitamin D represent potential options, but more studies are required to elucidate their roles in the management of this condition.

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The myo-inositol effect on the oocyte quality and fertilization rate among women with polycystic ovary syndrome undergoing assisted reproductive technology cycles: a randomized clinical trial

Sene

Tabatabaie

Nikniaz

et al. 2019

Arch Gynecol Obstet

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Oocyte quality and embryo quality of infertile women with polycystic ovarian syndrome

Cited by 3 publications

References 0 publications

Establishing an Anti-Müllerian hormone cutoff for diagnosis of polycystic ovarian syndrome in women of reproductive age-bearing Indian ethnicity using the automated Anti-Müllerian hormone assay

Establishing an Anti-Müllerian hormone cutoff for diagnosis of polycystic ovarian syndrome in women of reproductive age-bearing Indian ethnicity using the automated Anti-Müllerian hormone assay

Systematic Review of the roles of Inositol and Vitamin D in improving fertility among patients with Polycystic Ovary Syndrome

The myo-inositol effect on the oocyte quality and fertilization rate among women with polycystic ovary syndrome undergoing assisted reproductive technology cycles: a randomized clinical trial

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