Oocyte quality evaluation: a review of engineering approaches toward clinical challenges

Abstract

Although assisted reproductive technology has been very successful for the treatment of infertility, its steps are still dependent on direct human opinion. An important step of assisted reproductive treatments in lab for women is choosing an oocyte that has a better quality. This step would predict which oocyte has developmental competence leading to healthy baby. Observation of the oocyte morphological quality indicators under microscope by an embryologist is the most common evaluation method of oocyte quality. Such subjective method which relies on embryologist’s experience may vary and leads to misdiagnosis. An alternative solution to eliminate human misjudging in traditional methods and overcome the limitations of them is always using engineering-based procedure. In this review article, was deep studied and categorized engineering-based methods applied for the evaluation of oocyte quality. Then, the challenges in laboratories and clinics settings move forward with translational medicine perspective in mind for all those methods which had been studied were discussed. Finally, a standardized process was presented may help improving and focusing research in this field. Moreover, effective suggestion techniques were introduced that are expect they would be complementary methods to accelerate future researches. The aim of this review was to create a new prospect with the engineering approaches to evaluate oocyte quality and we hope this would help infertile couples to get a baby.

The Positive Effects of In Vivo/In Vitro Suplementation of Nanoparticles on Semen

“…Additionally, Morimoto et al (2023) found that mitochondrial transfer to human oocytes leads to acceptable clinical outcomes, enhancing embryo quality. Moreover, Palay et al (2022) have experimentally employed engineering-based models to estimate oocyte quality. Thus, implementing nanomaterials in IVF treatment has the potential to boost the oocyte quality and unlock better success rates.…”

Simple bioelectrical microsensor: oocyte quality prediction via membrane electrophysiological characterization

“…Despite progress in improving these methods, approximately 60 to 70 percent of couples seeking treatment at ART clinics are still unable to have a healthy baby. 1,2 Identifying the best quality gametes, both male gametes (sperm) and female gametes (oocytes), is one of the main crucial elements of developing successful in vitro fertilization (IVF). This fact is also observed in another aspect, oocyte quality is especially vital as it impacts early embryo development potential.…”

“…Our latest article offers an in-depth review and analysis of these methods. 2 The mechanical properties of the zona pellucida and cells, as well as the deformation of egg cells due to mechanical pressure, were studied to assess their hardness. Various methods like indentation, tension, constriction, or vibration 11,[14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] were employed to apply mechanical pressure.…”

“…Despite progress in improving these methods, approximately 60 to 70 percent of couples seeking treatment at ART clinics are still unable to have a healthy baby. 1,2…”