“…In addition to its inherent disadvantages like membrane exposure, other drawbacks like technical difficulties in placing the membrane over the defect, variations in defect morphology, varied results obtained through various studies and case reports, with respect to its regenerative potential, preclude the use of these membranes in all the cases with periodontal defects. 1 In this context, it is to be noted that PRF can be used in the form of membrane, and when used properly, found to release same or increased amount of growth factors than gel form. 7 Moreover, when compared to barrier membranes, this is autologous, easy to prepare and there is no risk of infection when exposed to oral cavity and till now we do not find any isolated case reports or other well designed studies where in PRF was tried to cover dehiscence or to treat periodontal defects excluding few animal studies where PRF was mixed with bone grafts in artificially induced defects.…”