Open-Label Three Arm Trial Comparing Ormeloxifene, Gamma Linolenic Acid With Methylcobalamine + Vitamin C and Placebo in Mastalgia

Abstract

Points• Centchroman, also known as Ormeloxifene, is a relatively new drug under the class of non-steroidal selective estrogen receptor modulators which is being used to treat mastalgia. •We evaluated the beneficial effect of Ormeloxifene (Centchroman) versus a combination of Gamma Linolenic acid (GLA), methylcobalamine and vitamin C on mastalgia in a three-arm, open-label, placebo-controlled trial.• In this study Ormeloxifene was not superior to GLA or placebo and was also associated with concerning side effects.