Open-Ring Butenolides from a Marine-Derived Anti-Neuroinflammatory Fungus Aspergillus terreus Y10

Yang, Likun; Ouyang, Han; Yan, Xiaojun; Tang, Bowen; Fang, Meijuan; Wu, Zhixian; Chen, Jingwei; Qiu, Ying-Kun

doi:10.3390/md16110428

Cited by 24 publications

(13 citation statements)

References 24 publications

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“…Conformational analyses and density functional theory (DFT) calculations were used to generate and optimize the conformers with energy. The ECD calculations were performed as previously described [31,32].…”

Section: Methodsmentioning

confidence: 99%

Two New Cytotoxic Compounds from a Deep-Sea Penicillum citreonigrum XT20-134

et al. 2019

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Penicillum citreonigrum XT20-134 (MCCC 3A00956) is a fungus with cytotoxic activity, derived from deep-sea sediment. Five new compounds, adeninylpyrenocine (1), 2-hydroxyl-3-pyrenocine-thio propanoic acid (2), ozazino-cyclo-(2,3-dihydroxyl-trp-tyr) (3), 5,5-dichloro-1-(3,5-dimethoxyphenyl)-1,4-dihydroxypentan-2-one (4), and 2,3,4-trihydroxybutyl cinnamate (5), together with 19 known compounds (6–24), were isolated from an ethyl acetate (EtOAc) extract of its fermentation. The structures of the new compounds were comprehensively characterized by high-resolution electrospray ionization-mass spectrometry (HR-ESI-MS), 1D and 2D nuclear magnetic resonance (NMR). All isolates were evaluated for their cytotoxic activities. The heteroatom-containing new compounds 2 and 4 showed potent cytotoxicity to the human hepatoma tumor cell Bel7402 with IC50 values of 7.63 ± 1.46, 13.14 ± 1.41 μM and the human fibrosarcoma tumor cell HT1080 with IC50 values of 10.22 ± 1.32, 16.53 ± 1.67 μM, respectively.

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Section: Methodsmentioning

confidence: 99%

Two New Cytotoxic Compounds from a Deep-Sea Penicillum citreonigrum XT20-134

et al. 2019

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“…Three new compounds with novel open-ring butenolide skeletons were isolated from Aspergillus terreus Y10 (coastal area of Hainan, the South China Sea). One of them, asperteretal F (153) was found to dose-dependently inhibit tumor necrosis factor (TNF-α) generation [91]. Asperversiamide G (154) (Figure 14), possessing an unusual pyrano[3,2-f]indole unit, was isolated from Aspergillus versicolor (the South China Sea) and exhibited a potent inhibitory effect against iNO synthase [92].…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Metabolites of Marine Sediment-Derived Fungi: Actual Trends of Biological Activity Studies

2021

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Marine sediments are characterized by intense degradation of sedimenting organic matter in the water column and near surface sediments, combined with characteristically low temperatures and elevated pressures. Fungi are less represented in the microbial communities of sediments than bacteria and archaea and their relationships are competitive. This results in wide variety of secondary metabolites produced by marine sediment-derived fungi both for environmental adaptation and for interspecies interactions. Earlier marine fungal metabolites were investigated mainly for their antibacterial and antifungal activities, but now also as anticancer and cytoprotective drug candidates. This review aims to describe low-molecular-weight secondary metabolites of marine sediment-derived fungi in the context of their biological activity and covers research articles published between January 2016 and November 2020.

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“…The chemical structures of these compounds were recently elucidated and their effects against the expression of TNFα in lipopolysaccharide (LPS)-activated BV2 microglia cells were tested. The most promising compound was asperteretal F, which inhibited the expression of TNFα in a dose-dependent mode, making it an anti-neuroinflammatory candidate for the treatment of NDs [ 23 ].…”

Section: Natural Compounds and Neurodegenerative Diseasesmentioning

confidence: 99%

Natural Compounds for the Prevention and Treatment of Cardiovascular and Neurodegenerative Diseases

Leuci

Brunetti

Poliseno

et al. 2020

Foods

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Secondary metabolites from plants and fungi are stimulating growing interest in consumers and, consequently, in the food and supplement industries. The beneficial effects of these natural compounds are being thoroughly studied and there are frequent updates about the biological activities of old and new molecules isolated from plants and fungi. In this article, we present a review of the most recent literature regarding the recent discovery of secondary metabolites through isolation and structural elucidation, as well as the in vitro and/or in vivo evaluation of their biological effects. In particular, the possibility of using these bioactive molecules in the prevention and/or treatment of widely spread pathologies such as cardiovascular and neurodegenerative diseases is discussed.

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Open-Ring Butenolides from a Marine-Derived Anti-Neuroinflammatory Fungus Aspergillus terreus Y10

Cited by 24 publications

References 24 publications

Two New Cytotoxic Compounds from a Deep-Sea Penicillum citreonigrum XT20-134

Two New Cytotoxic Compounds from a Deep-Sea Penicillum citreonigrum XT20-134

Metabolites of Marine Sediment-Derived Fungi: Actual Trends of Biological Activity Studies

Natural Compounds for the Prevention and Treatment of Cardiovascular and Neurodegenerative Diseases

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